Document Detail

Extensive thrombus formation in the right ventricle due to a rare combination of arrhythmogenic right ventricular cardiomyopathy and heterozygous prothrombin gene mutation G20210 A.
MedLine Citation:
PMID:  10894919     Owner:  NLM     Status:  MEDLINE    
Arrhythmogenic right ventricular cardiomyopathy is a rare heart muscle disease characterized by right and often left ventricular myocardial atrophy and fibrofatty replacement. Heart failure, arrhythmias and sudden death are characteristic complications. We observed a female in whom arrhythmogenic right ventricular cardiomyopathy was diagnosed due to presyncopes and dyspnea on exertion. A left ventricular thrombus was found echocardiographically, which disappeared with oral anticoagulation. Subsequently, however, extensive thrombus formation in the dilated akinetic right ventricle occurred which was resistant to combined treatment with heparin and oral anticoagulation. Thrombophilia screening showed a mutant prothrombin 20210A allele which is an inherited coagulopathy associated with increased plasma levels of prothrombin and increased risks of mainly venous thrombosis. The patient developed endstage biventricular heart failure and underwent heart transplantation within 3 months after thrombus formation in the right ventricle was diagnosed. In the explanted heart, the thrombus in the right ventricle was impressively large and calcified. In patients with unusual thrombus formation in the heart, coagulopathy may be associated and should be excluded.
C H Attenhofer Jost; T Bombeli; C Schrimpf; E Oechslin; W Kiowski; R Jenni
Related Documents :
16442409 - Transthoracic echocardiographic predictors of left atrial appendage thrombus.
7073369 - Right ventricular myxoma: review of the literature and report of two patients.
7377889 - The distribution patterns of biatrial myxomas.
18949089 - A right atrial hemangioma mimicking thrombus in a patient with atrial arrhythmias.
10150999 - Selective coronary angiography in intracardiac tumors.
16020889 - A japanese case of familial cardiac myxoma associated with a mutation of the prkar1alph...
19808379 - Characterization of an extensive transverse tubular network in sheep atrial myocytes an...
2026029 - Oxygen consumption in sepsis and septic shock.
12504269 - Cardiac surgery: myocardial energy balance, antioxidant status and endothelial function...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  93     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-13     Completed Date:  2000-09-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  127-30     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Division of Cardiology, University Hospital Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arrhythmogenic Right Ventricular Dysplasia / blood,  complications*,  genetics,  surgery
Heart Diseases / blood,  etiology,  surgery
Heart Transplantation
Point Mutation*
Prothrombin / genetics*,  metabolism
Thrombosis / blood,  etiology*,  surgery
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dangerous impact--commotio cordis.
Next Document:  Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glu...