Document Detail

Extensive thrombus formation in the right ventricle due to a rare combination of arrhythmogenic right ventricular cardiomyopathy and heterozygous prothrombin gene mutation G20210 A.
MedLine Citation:
PMID:  10894919     Owner:  NLM     Status:  MEDLINE    
Arrhythmogenic right ventricular cardiomyopathy is a rare heart muscle disease characterized by right and often left ventricular myocardial atrophy and fibrofatty replacement. Heart failure, arrhythmias and sudden death are characteristic complications. We observed a female in whom arrhythmogenic right ventricular cardiomyopathy was diagnosed due to presyncopes and dyspnea on exertion. A left ventricular thrombus was found echocardiographically, which disappeared with oral anticoagulation. Subsequently, however, extensive thrombus formation in the dilated akinetic right ventricle occurred which was resistant to combined treatment with heparin and oral anticoagulation. Thrombophilia screening showed a mutant prothrombin 20210A allele which is an inherited coagulopathy associated with increased plasma levels of prothrombin and increased risks of mainly venous thrombosis. The patient developed endstage biventricular heart failure and underwent heart transplantation within 3 months after thrombus formation in the right ventricle was diagnosed. In the explanted heart, the thrombus in the right ventricle was impressively large and calcified. In patients with unusual thrombus formation in the heart, coagulopathy may be associated and should be excluded.
C H Attenhofer Jost; T Bombeli; C Schrimpf; E Oechslin; W Kiowski; R Jenni
Related Documents :
7073369 - Right ventricular myxoma: review of the literature and report of two patients.
15505839 - Improved performance of a new thrombus aspiration catheter: outcomes from in vitro expe...
19545349 - Giant left atrial thrombus associated with ablation for atrial tachycardia.
17988989 - Successful imatinib treatment of cardiac involvement of fip1l1-pdgfra-positive chronic ...
15227359 - The echocardiographic spectrum of atrial myxoma: a ten-year experience.
20675399 - Giant left atrial thrombus 17 years after orthotopic heart transplantation.
12638679 - Drug-induced toxic myocarditis.
10666659 - Catheter ablation in the year 2000.
14575299 - Modulation of cardiac remodeling by adenosine: in vitro and in vivo effects.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  93     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2000  
Date Detail:
Created Date:  2000-09-13     Completed Date:  2000-09-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  127-30     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Division of Cardiology, University Hospital Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arrhythmogenic Right Ventricular Dysplasia / blood,  complications*,  genetics,  surgery
Heart Diseases / blood,  etiology,  surgery
Heart Transplantation
Point Mutation*
Prothrombin / genetics*,  metabolism
Thrombosis / blood,  etiology*,  surgery
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dangerous impact--commotio cordis.
Next Document:  Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glu...