| Extensive spontaneous occlusive arteriosclerosis of the lingual arteries in Fischer rats, a model for the study of human occlusive arteriosclerosis of medium- and small-sized arteries. | |
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MedLine Citation:
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PMID: 2069519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous occlusive arteriosclerosis is rarely present in rats or other laboratory rodents. Instead, the common vascular lesion in these animals is a mineralization resembling Mönkeberg's medial calcinosis, or non-atheromatous and non-obstructive arteriosclerosis. For reasons yet unknown, the lingual arteries of Fischer rats behave differently; they develop extensive sclerotic lesions with progressive narrowing of the lumen, leading to complete occlusion and sometimes recanalization, comparable to lesions seen in human coronaries, carotids, tibials, etc. The spontaneous plaque-forming, thrombotic, occlusive arteriosclerosis of the lingual artery in Fischer rats can serve as an experimental model for the same lesion of medium- and small-sized arteries in man. As such, it can considerably facilitate the testing of nutritional, hormonal, immunological and other chemical or physical factors for a possible role in promoting or inhibiting the thrombotic-occlusive arteriopathy in man. |
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Authors:
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A Rivenson; D Hoffmann |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Artery Volume: 18 ISSN: 0098-6127 ISO Abbreviation: Artery Publication Date: 1991 |
Date Detail:
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Created Date: 1991-08-15 Completed Date: 1991-08-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7508494 Medline TA: Artery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 150-62 Citation Subset: IM |
Affiliation:
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American Health Foundation, Valhalla, New York 10595. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects*, pathology Arteriosclerosis / chemically induced*, pathology Arteritis / pathology Disease Models, Animal Giant Cells / pathology Male Nicotine / toxicity* Rats Rats, Inbred F344 Tongue / blood supply*, pathology |
| Grant Support | |
ID/Acronym/Agency:
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CA-29580/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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