Document Detail

Extensive reduction of cell viability and enhanced matrix production in Pseudomonas aeruginosa PAO1 flow biofilms treated with a D-amino acid mixture.
MedLine Citation:
PMID:  23220960     Owner:  NLM     Status:  MEDLINE    
Treatment of Pseudomonas aeruginosa PAO1 flow biofilms with a D-amino acid mixture caused significant reductions in cell biomass by 75% and cell viability by 71%. No biofilm disassembly occurred, and matrix production increased by 30%, thereby providing a thick protective cover for remaining viable or persister cells.
Zoe Sanchez; Akio Tani; Kazuhide Kimbara
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-07
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  79     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-08     Revised Date:  2013-08-11    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1396-9     Citation Subset:  IM    
Department of Materials Science and Chemical Engineering, Shizuoka University, Hamamatsu, Japan.
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MeSH Terms
Amino Acids / metabolism*
Biofilms / drug effects*
Extracellular Matrix / metabolism*
Microbial Viability / drug effects*
Pseudomonas aeruginosa / drug effects*,  metabolism,  physiology*
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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