Document Detail

Extensive involvement of the myocardium and the cardiac conduction system in a case of Wegener's granulomatosis.
MedLine Citation:
PMID:  10611918     Owner:  NLM     Status:  MEDLINE    
A 61-year-old female who had shown Raynaud's phenomenon and articular swelling for 10 years, was admitted to hospital because of fever of unknown origin (FUO) and dry cough. She was diagnosed by skin biopsy to have a collagen disease or overlap syndrome. Anemia developed rapidly and FUO persisted, but blood culture was negative. Although indomethacin and prednisolone were administered for the progression of clinical signs and symptoms, severe dyspnea developed, resulting in bradycardia, followed by recurrent episodes of ventricular tachycardia. In spite of extensive treatment for her arrhythmia she died on the 9th hospital day. An autopsy revealed generalized Wegener's granulomatosis with extensive cardiac involvement. Necrotizing angitis and severe granulomatous inflammatory foci affected characteristically the common bundle of His and right bundle branch in addition to the ordinary myocardium.
S Ohkawa; M Miyao; K Chida; T Mizuuchi; K Kida; K Takubo; K Ohtsubo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  40     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2000-01-05     Completed Date:  2000-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  IM    
Division of Cardiology, Tokyo Metropolitan Geriatric Hospital, Japan.
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MeSH Terms
Heart Conduction System / pathology*
Middle Aged
Myocardium / pathology*
Wegener Granulomatosis / pathology*,  physiopathology

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