Document Detail


Extensive inflammatory cell infiltration in human skeletal muscle in response to an ultraendurance exercise bout in experienced athletes.
MedLine Citation:
PMID:  23104690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The impact of a 24-h ultraendurance exercise bout on systemic and local muscle inflammatory reactions was investigated in nine experienced athletes. Blood and muscle biopsies were collected before (Pre), immediately after the exercise bout (Post), and after 28 h of recovery (Post28). Circulating blood levels of leukocytes, creatine kinase (CK), C-reactive protein (CRP), and selected inflammatory cytokines were assessed together with the evaluation of the occurrence of inflammatory cells (CD3(+), CD8(+), CD68(+)) and the expression of major histocompatibility complex class I (MHC class I) in skeletal muscle. An extensive inflammatory cell infiltration occurred in all athletes, and the number of CD3(+), CD8(+), and CD68(+) cells were two- to threefold higher at Post28 compared with Pre (P < 0.05). The inflammatory cell infiltration was associated with a significant increase in the expression of MHC class I in muscle fibers. There was a significant increase in blood leukocyte count, IL-6, IL-8, CRP, and CK at Post. At Post28, total leukocytes, IL-6, and CK had declined, whereas IL-8 and CRP continued to increase. Increases in IL-1β and TNF-α were not significant. There were no significant associations between the magnitude of the systemic and local muscle inflammatory reactions. Signs of muscle degenerative and regenerative events were observed in all athletes with various degrees of severity and were not affected by the 24-h ultraendurance exercise bout. In conclusion, a low-intensity but very prolonged single-endurance exercise bout can generate a strong inflammatory cell infiltration in skeletal muscle of well-trained experienced ultraendurance athletes, and the amplitude of the local reaction is not proportional to the systemic inflammatory response.
Authors:
Peter Marklund; C Mikael Mattsson; Britta Wåhlin-Larsson; Elodie Ponsot; Björn Lindvall; Lisbeth Lindvall; Björn Ekblom; Fawzi Kadi
Publication Detail:
Type:  Journal Article     Date:  2012-10-25
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  114     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-07-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  66-72     Citation Subset:  IM    
Affiliation:
School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / metabolism
Athletes*
C-Reactive Protein / metabolism
Creatine Kinase / metabolism
Exercise / physiology*
Genes, MHC Class I
Humans
Inflammation / genetics,  metabolism,  pathology*
Interleukin-1beta / metabolism
Interleukin-6 / metabolism
Interleukin-8 / metabolism
Leukocyte Count / methods
Leukocytes / metabolism,  pathology
Male
Muscle, Skeletal / metabolism,  pathology*
Tumor Necrosis Factor-alpha / metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/IL6 protein, human; 0/Interleukin-1beta; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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