Document Detail

Extensive diversification of IgH subclass-encoding genes and IgM subclass switching in crocodilians.
MedLine Citation:
PMID:  23299887     Owner:  NLM     Status:  In-Data-Review    
Crocodilians are a group of reptiles that are closely related to birds and are thought to possess a strong immune system. Here we report that the IgH locus in the Siamese crocodile and the Chinese alligator contains multiple μ genes, in contrast to other tetrapods. Both the μ2 and μ3 genes are expressed through class-switch recombination involving the switch region and germline transcription. Both IgM1 and IgM2 are present in the serum as polymers, which implies that IgM class switching may have significant roles in humoural immunity. The crocodilian α genes are the first IgA-encoding genes identified in reptiles, and these genes show an inverted transcriptional orientation similar to that of birds. The identification of both α and δ genes in crocodilians suggests that the IgH loci of modern living mammals, reptiles and birds share a common ancestral organization.
Gang Cheng; Yang Gao; Tao Wang; Yi Sun; Zhiguo Wei; Lingxiao Li; Liming Ren; Ying Guo; Xiaoxiang Hu; Yan Lu; Xumin Wang; Guiming Liu; Chenglin Zhang; Jun Yu; Qiang Pan-Hammarström; Lennart Hammarström; Xiaobing Wu; Ning Li; Yaofeng Zhao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature communications     Volume:  4     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  1337     Citation Subset:  IM    
State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, China.
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