Document Detail


Extensive cortical inflammation is associated with epilepsy in multiple sclerosis.
MedLine Citation:
PMID:  18227989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Epilepsy is three to six times more frequent in MS than in the general population. Previous studies based on conventional magnetic resonance (MR) imaging have suggested a possible correlation between cortical inflammatory pathology and epileptic seizures. However, pure intracortical lesions (ICLs) are unlikely to be demonstrated with conventional MR. We applied the double inversion recovery (DIR) sequence in relapsing remitting MS (RRMS) patients with or without epileptic seizures in order to clarify the relationship between ICLs and epilepsy in MS in vivo. METHODS: Twenty RRMS patients who had epileptic seizures (RRMS/E) during the course of the disease were studied for the presence of ICLs. A group of 80 RRMS patients with no history of seizures and matched for gender, age, disease duration, Expanded Disability Status Scale (EDSS) grading, and T2 lesion volume (T2-WMLV) was selected as reference population. ICLs were detected by applying the DIR sequence. RESULTS: ICLs were observed in 18/20 (90%) RRMS/E and in 39/80 (48%) RRMS (p = 0.001). RRMS/E showed five times more ICLs (7.2 +/- 8.4) than RRMS (1.5 +/- 2.4; p = 0.015). The total ICLs volume was 6 times larger in RRMS/E than in RRMS (1.2 +/- 1.7 cm3 versus 0.2 +/- 0.2 cm3, p = 0.016). No significant difference was observed between RRMS and RRMS/E with regard to the number and volume of juxtacortical lesions and T2-WMLV. DISCUSSION: Our findings indicate that RRMS/E have more extensive cortical inflammation than RRMS patients with no history of epilepsy. Inflammatory ICLs may be responsible for epilepsy in MS.
Authors:
Massimiliano Calabrese; Nicola De Stefano; Matteo Atzori; Valentina Bernardi; Irene Mattisi; Luigi Barachino; Luciano Rinaldi; Aldo Morra; Matthew M J McAuliffe; Paola Perini; Leontino Battistin; Paolo Gallo
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Publication Detail:
Type:  Journal Article     Date:  2008-01-31
Journal Detail:
Title:  Journal of neurology     Volume:  255     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-07-01     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  581-6     Citation Subset:  IM    
Affiliation:
The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Dept. of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy. calabresem@hotmail.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / immunology,  pathology,  physiopathology
Brain Mapping / methods
Causality
Comorbidity
Disease Progression
Electroencephalography
Encephalitis / diagnosis*,  epidemiology,  physiopathology
Epilepsy / diagnosis*,  epidemiology,  physiopathology
Female
Humans
Italy / epidemiology
Magnetic Resonance Imaging / methods
Male
Middle Aged
Multiple Sclerosis / diagnosis*,  epidemiology,  physiopathology
Predictive Value of Tests
Prevalence
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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