Document Detail

Extensive cardiopulmonary resuscitation for VLBW and ELBW infants: a systematic review and meta-analyses.
MedLine Citation:
PMID:  19554016     Owner:  NLM     Status:  MEDLINE    
Studies of the outcomes of preterm infants after the receipt of extensive cardiopulmonary resuscitation (CPR) at birth or in the neonatal intensive care units (NICUs) have yielded varied results. A systematic review of the outcomes of very low birth weight (VLBW) and extremely low birth weight (ELBW) infants who received extensive resuscitation at birth or in the NICU was carried out. MEDLINE, EMBASE, CINAHL databases were searched for studies of extensive CPR in the delivery room (DR-CPR) and in NICU (NICU-CPR) that have reported neonatal or long-term outcomes. A total of 20 eligible studies were identified (11 of DR-CPR, 7 of NICU-CPR and 2 had combined data). DR-CPR was associated with an increased risk of mortality (odds ratio (OR) 2.83, 95% confidence interval (CI) 1.92, 4.16) and severe neurological injury (OR 2.27, 95% CI 1.40, 3.67) compared with infants who did not receive extensive CPR. NICU-CPR was associated with an increased risk of mortality (OR 55, 95% CI 15, 195) compared with infants who did not receive CPR; however, confidence limits were wide. The long-term outcome of survivors was reported in a limited number of studies. Extensive CPR at birth or in the NICU for VLBW or ELBW infants was associated with higher risk of mortality.
P S Shah
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2009-06-25
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  29     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-61     Citation Subset:  IM    
Department of Pediatrics, Mount Sinai Hospital and University of Toronto, Ontario, Canada.
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MeSH Terms
Cardiopulmonary Resuscitation / adverse effects*,  mortality
Infant, Extremely Low Birth Weight*
Infant, Newborn
Infant, Very Low Birth Weight*
Intensive Care Units, Neonatal
Leukomalacia, Periventricular / etiology*
Odds Ratio

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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