Document Detail

Extensive brain swelling with neurological deterioration after intracranial meningioma surgery - venous complication or 'unspecific' increase in tissue permeability.
MedLine Citation:
PMID:  18393161     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We retrospectively analyzed a series of patients who deteriorated after resection of an intracranial meningioma due to extensive brain edema (EBE) with regard to etiology of the neurological worsening and outcome. METHODS: Out of a series of 376 consecutive patients who underwent resection of an intracranial meningioma, 13 (3.5%) experienced postoperative deterioration due to EBE which necessitated prolonged artificial ventilation, tracheal reintubation, or decompressive craniectomy. Clinical data, radiological findings, operative records and follow-up data of these patients were retrospectively reviewed. RESULTS: The study revealed two different patient groups: Patients in group A (n=7) demonstrated edema due to typical venous infarction (VI). A decompressive craniotomy was performed in all but one patient in this group; nonetheless, an acceptable neurological outcome (Glasgow Outcome Scale (GOS) 4) was achieved in only two cases. Patients in group B (n=6) deteriorated due to an EBE of unknown etiology. Mean tumor volume in this group was higher when compared to group A (75 ml vs. 30 ml). In addition, 83% of patients in group B displayed extensive preoperative peritumoral edema compared to only 14% in group A. Three patients in group B required decompressive surgery; however, neurological outcome was more favorable in this group as 83% achieved a GOS of 4 or 5. CONCLUSION: Extensive brain swelling during or after intracranial meningioma surgery may be due to VI or possibly due to increased postoperative tissue permeability. It is recommended to preserve all venous structures as patients with VI had an unfavorable neurological outcome.
S Asgari; H Bassiouni; A Hunold; D Klassen; D Stolke; I E Sandalcioglu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Neurochirurgie     Volume:  69     ISSN:  0044-4251     ISO Abbreviation:  Zentralbl. Neurochir.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413646     Medline TA:  Zentralbl Neurochir     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  22-9     Citation Subset:  IM    
Department of Neurosurgery, University Hospital Essen, Essen, Germany.
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MeSH Terms
Brain Edema / etiology*
Brain Neoplasms / pathology,  surgery*
Cerebral Infarction / etiology,  pathology
Cerebral Veins / pathology
Cerebrovascular Disorders / etiology*
Data Interpretation, Statistical
Follow-Up Studies
Glasgow Outcome Scale
Magnetic Resonance Imaging
Meningioma / pathology,  surgery*
Middle Aged
Nervous System Diseases / etiology*
Neurosurgical Procedures / adverse effects*
Postoperative Complications / epidemiology*
Retrospective Studies
Tomography, X-Ray Computed
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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