| Extensive Fibrin Accumulation and Accompanying Epithelial Changes in the Pathogenesis of Ligneous Mucosal Disease (Ligneous Periodontitis). | |
| | |
MedLine Citation:
|
PMID: 21993334 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Certain abnormal products of human tissues are resistant to degradation. The fibrillary ultrastructure of some of these are seen integrated with normal tissue components. The accumulations seen in colloid milium, lichen, and macular amyloidosis are of this type. Apoptosis of keratinocytes and filamentous degeneration of some proteins can be important in the pathogenesis. A similar pathogenetic mechanism is possible in ligneous mucosal disease, which is a rare disorder of plasminogen deficiency characterized by amyloid-like amorphous accumulations. Gingival and conjunctival mucosal pseudomembraneous masses are typical and concomitant involvement of other sites are not unusual. The accumulated substance is thought to be an abnormal fibrin degradation product. In this study, we have examined 6 representative samples from 5 gingival and 1 conjunctival lesions displaying characteristic features. Immunohistochemically, fibrinogen was detected as an early change. TUNEL staining revealed numerous apoptotic keratinocytes in this phase as well. These cells also expressed nuclear factor kappa beta. Apoptotic cells showed loss of epithelial cadherin immunostaining. In the later phase, the subepithelial accumulations failed to stain with antifibrinogen, wide spectrum, and high molecular keratins, type 4 collagen and nuclear factor kappa beta. Our findings suggest that the accumulations in ligneous mucosal disorder result from an abnormal healing process and they probably form as a combination of organised fibrinogen, epithelial fragments, and connective tissue matrix. |
| | |
Authors:
|
Omer Günhan; Arzu Avci; Omür Dereci; Sivge Akgün; Bülent Celasun |
Related Documents
:
|
7850934 - Human responses to bacterial endotoxin. 17380794 - Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sep... 10807314 - Lipid mediators in the pathophysiology of critical illness. 12462554 - Early circulating lymphocyte apoptosis in human septic shock is associated with poor ou... 11285224 - Mechanism for down-regulation of cd28 by nef. 15962304 - Topoisomerase inhibitor induced dephosphorylation of h1 and h3 histones as a consequenc... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-11 |
Journal Detail:
|
Title: The American Journal of dermatopathology Volume: - ISSN: 1533-0311 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the *Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey; †Department of Pathology, Atatürk Research and Education Hospital, İzmir, Turkey; ‡Department of Oral and Maxillofacial Surgery, Ankara University, Faculty of Dentistry, Ankara, Turkey; §Department of Periodontology, Ankara University, Faculty of Dentistry, Ankara, Turkey; and ‖Gören Pathology Laboratory, Ankara, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced weak localization effect in few-layer graphene.
Next Document: Mucocutaneous Pseudoepitheliomatous Hyperplasia: A Review.