| Extensive extramedullary disease involving the colon in multiple myeloma: a case report and review of literature. | |
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MedLine Citation:
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PMID: 20703830 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Organ involvement in multiple myeloma (MM) is characterized by infiltrative disease or by a myelomatous mass known as a plasmacytoma. We present a patient with MM who had extensive extramedullary involvement of the colon and a review of the literature on colon plasmacytomas. CASE REPORT: A 57-year-old male with MM presented with disease relapse in 2007, workup showing biopsy confirmed left perinephric extra-medullary disease involving the adjacent colon. Positron emission-tomography (PET) exhibited intense pan-colonic fluoro-deoxyglucose (FDG) uptake and computed-tomography confirmed extensive infiltrating soft tissue thickening in the ascending, transverse, and descending colon representing plasmacytomas. The patient underwent an autologous hematopoietic stem cell transplantation after conditioning with high-dose melphalan. Restaging PET-scan showed complete resolution of colonic extra-medullary plasmacytomas. Extramedullary plasmacytomas (EMP) are rare and constitute 4% of all plasma cell tumors. DISCUSSION AND CONCLUSION: Colonic plasmacytoma is an extremely rare site, with fewer than 25 cases reported in the literature. Colonic plasmacytomas have different presentations depending on the size and location. Treatment options for primary EMPs include surgical resection, radiotherapy, and chemotherapy. The primary treatment option for secondary EMP is systemic chemotherapy. This rare pan-colonic plasmacytoma, as a part of extramedullary myeloma, showed an impressive response to chemotherapy. |
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Authors:
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Bobby R Kakati; Kavya Krishna; Somashekar G Krishna; Shree G Sharma; Naveen Sanathkumar; Rayburn F Rego |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastrointestinal cancer Volume: 43 ISSN: 1941-6636 ISO Abbreviation: J Gastrointest Cancer Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479627 Medline TA: J Gastrointest Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 379-81 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot #567, Little Rock, AR, 72205, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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