| Extension of life span and improvement of vitality of Drosophila melanogaster by long-term supplementation with different molecular weight polysaccharides from Porphyra haitanensis. | |
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MedLine Citation:
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PMID: 18221885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polysaccharides isolated from Porphyra (porphyran) have been known to have diverse biological activities, including immunomodulatory and antioxidant activities. The molecular weight-antiaging activity relationship of degraded porphyrans was examined in this study. Natural porphyran was extracted from P. haitanensis, and then was degraded into different molecular weight fractions, P1 molecular weight 49 kDa, P2 molecular weight 30 kDa, P3 molecular weight 8.2 kDa, by free radical. The influence on life span and vitality of porphyrans were carried out on Drosophila melanogaster. We found that all the degraded porphyrans and natural porphyran (P), added daily to the diet, can significantly increase the life span of D. melanogaster, except for P3. Among them, P1 exhibited the most prolonging life span activity. Furthermore, vitality of middle-aged flies (assessed by measuring their mating capacity) receiving porphyrans was increased considerably in comparison with the controls. Finally, in the heat-stress test, we observed a remarkable increase in survival time, especially in P3-diet groups. These results suggest that porphyrans may be effective in reducing the rate of the aging process and molecular weight has important influence on the effects. It seems that P1 and P2, possessed higher molecular weight, may be more useful in normal metabolic condition and P3, possessed the lowest molecular weight, may be more beneficial for D. melanogaster in stress condition. |
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Authors:
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Tingting Zhao; Quanbin Zhang; Huimin Qi; Xiguang Liu; Zhien Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-23 |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 57 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-04-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila melanogaster Female Hot Temperature Longevity / drug effects* Male Molecular Weight Polysaccharides / pharmacology* Porphyra* Sexual Behavior, Animal / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Polysaccharides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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