| Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry. | |
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MedLine Citation:
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PMID: 20617125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progress in genome research led to new perspectives in diagnostic applications and to new promising therapies. On account of their specificity and sensitivity, nucleic acids (DNA/RNA) increasingly are in the focus of the scientific interest. While nucleic acids were a target of therapeutic interventions up to now, they could serve as excellent tools in the future, being highly sequence-specific in molecular diagnostics. Examples for imaging modalities are the representation of metabolic processes (Molecular Imaging) and customized therapeutic approaches ("Targeted Therapy"). In the individualized medicine nucleic acids could play a key role; this requires new properties of the nucleic acids, such as stability. Due to evolutionary reasons natural nucleic acids are substrates for nucleases and therefore suitable only to a limited extent as a drug. To use DNA as an excellent drug, modifications are required leading e.g. to a peptide nucleic acid (PNA). Here we show that an easy substitution of nucleobases by functional molecules with different reactivity like the Reppe anhydride and pentenoic acid derivatives is feasible. These derivatives allow an independent multi-ligation of functionalized compounds, e.g. pharmacologically active ones together with imaging components, leading to local concentrations sufficient for therapy and diagnostics at the same time. The high chemical stability and ease of synthesis could enhance nucleic chemistry applications and qualify PNA as a favourite for delivery. This system is not restricted to medicament material, but appropriate for the development of new and highly efficient drugs for a sustainable pharmacy. |
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Authors:
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Manfred Wiessler; Waldemar Waldeck; Ruediger Pipkorn; Christian Kliem; Peter Lorenz; Heinz Fleischhacker; Manuel Hafner; Klaus Braun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-27 |
Journal Detail:
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Title: International journal of medical sciences Volume: 7 ISSN: 1449-1907 ISO Abbreviation: Int J Med Sci Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-09-15 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 101213954 Medline TA: Int J Med Sci Country: Australia |
Other Details:
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Languages: eng Pagination: 213-23 Citation Subset: IM |
Affiliation:
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German Cancer Research Center, Dept. of Imaging and Radiooncology, INF 280, D-69120 Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Molecular Structure Peptide Nucleic Acids / chemical synthesis, chemistry* Polymers / chemical synthesis, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Peptide Nucleic Acids; 0/Polymers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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