Document Detail


Extending synthetic routes for oligosaccharides by enzyme, substrate and reaction engineering.
MedLine Citation:
PMID:  20182930     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The integration of all relevant tools for bioreaction engineering has been a recent challenge. This approach should notably favor the production of oligo- and polysaccharides, which is highly complex due to the requirements of regio- and stereoselectivity. Oligosaccharides (OS) and polysaccharides (PS) have found many interests in the fields of food, pharmaceuticals, and cosmetics due to different specific properties. Food, sweeteners, and food ingredients represent important sectors where OS are used in major amounts. Increasing attention has been devoted to the sophisticated roles of OS and glycosylated compounds, at cell or membrane surfaces, and their function, e.g., in infection and cancer proliferation. The challenge for synthesis is obvious, and convenient approaches using cheap and readily available substrates and enzymes will be discussed. We report on new routes for the synthesis of oligosaccharides (OS), with emphasis on enzymatic reactions, since they offer unique properties, proceeding highly regio- and stereoselective in water solution, and providing for high yields in general.
Authors:
Jürgen Seibel; Hans-Joachim Jördening; Klaus Buchholz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in biochemical engineering/biotechnology     Volume:  120     ISSN:  1616-8542     ISO Abbreviation:  Adv. Biochem. Eng. Biotechnol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307733     Medline TA:  Adv Biochem Eng Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  163-93     Citation Subset:  IM    
Affiliation:
Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany, seibel@chemie.uni-wuerzburg.de.
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