| Extended use dexamethasone-associated posterior reversible encephalopathy syndrome with cisplatin-based chemotherapy. | |
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MedLine Citation:
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PMID: 19800799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a normotensive patient who developed posterior reversible encephalopathy syndrome following prolonged use of dexamethasone for nausea control with cisplatin and pemetrexed chemotherapy. A 32-year-old woman with advanced intraperitoneal mesothelioma developed new-onset seizures and cognitive impairment. MRI of the brain demonstrated several areas of increased signal on T2-weighted and fluid-attenuated inversion recovery sequences within the subcortical white matter of both hemispheres. Chemotherapy was discontinued and dexamethasone tapered-off. She returned to her baseline with resolution of MRI abnormalities. We hypothesize that extended use of dexamethasone potentiated the relatively uncommon complication of leukotoxicity associated with cisplatin, and we elaborate on dexamethasone's contribution. |
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Authors:
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MyChau T Nguyen; Irim Y Virk; Lita Chew; J Lee Villano |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-10-02 |
Journal Detail:
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Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 16 ISSN: 1532-2653 ISO Abbreviation: J Clin Neurosci Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
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Languages: eng Pagination: 1688-90 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, The University of Illinois at Chicago, Chicago, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Agents, Hormonal / adverse effects* Cisplatin / adverse effects* Dexamethasone / adverse effects* Female Humans Magnetic Resonance Imaging / methods Nausea / drug therapy Posterior Leukoencephalopathy Syndrome / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Hormonal; 15663-27-1/Cisplatin; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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