Document Detail

Extended spectrum beta lactamase producing Klebsiella pneumoniae in neonatal intensive care unit.
MedLine Citation:
PMID:  17699969     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: As infections due to Extended Spectrun beta Lactamase (ESbetaL) producing Klebsiella pneumoniae were increasing in the NICU at Karnataka Institute of Medical Sciences Hospital, Hubli, India, the present study was carried out to identify any environmental sources and the mode of transmission. METHODS: Environmental samples from various sites were collected monthly for a period of six months. RESULTS: ESbetaL producing K. pneumoniae were isolated from all the sites except room air at least on one occasion. ESbetaL producing K. pneumoniae was always isolated from one of the incubators, medicine trolley and sink; while at least one of the health care workers carried it in the hands four out of six times tested. ESbeta L producing K. pneumoniae with similar antibiogram were also isolated from the clinical samples obtained from the neonates. CONCLUSION: Widespread use of third generation cephalosporins as a pre-emptive antibiotic for suspected cases of septicaemia may have contributed to emergence of ESbetaL producing K. pneumoniae in addition to other risk factors. ESbetaL producing K. pneumoniae have extensively colonised the environment of the NICU. Transmission of these pathogens to the neonates has probably occurred through the healthcare workers. Efforts to improve hand hygiene among the healthcare workers and mothers are urgently needed.
B V S Krishna; Asha B Patil; M R Chandrasekhar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  74     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-09-18     Revised Date:  2009-07-15    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  627-30     Citation Subset:  IM    
Department of Microbiology, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom.
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MeSH Terms
Cross Infection / microbiology*,  transmission
Drug Resistance, Multiple, Bacterial*
Equipment Contamination
Infant, Newborn
Intensive Care Units, Neonatal*
Klebsiella Infections / microbiology*,  transmission
Klebsiella pneumoniae / isolation & purification*,  metabolism
beta-Lactamases / metabolism*
Reg. No./Substance:

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