Document Detail


Extended-spectrum beta-lactamase-producing Enterobacteriaceae in different environments (humans, food, animal farms and sewage).
MedLine Citation:
PMID:  16720567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study aimed to determine the presence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in different environments. METHODS: Clinical samples and stool samples from animal farms, sewage, human faecal carriers attending the emergency room and faecal carriers in the context of food-borne disease outbreaks were subcultured onto MacConkey agar supplemented with cefotaxime for the detection of ESBL-producing Enterobacteriaceae. Identification, susceptibility pattern and ERIC-PCR were used for clone delineation in each sample. Community consumption of antibiotics was also recorded. RESULTS: An ESBL-producing Enterobacteriaceae prevalence of 1.9% was observed in human infections. A cross-sectional survey of human faecal carriers in the community showed a general prevalence of 6.6% with a temporal distribution. High use of antibiotics in winter coincided with a lower prevalence in carriers. ESBL-producing Enterobacteriaceae were detected in the five samples of human sewage, in samples from 8 of 10 pig farms, 2 of 10 rabbit farms, from all 10 poultry farms and in 3 of 738 food samples studied. Faecal carriage of ESBL-producing Enterobacteriaceae was detected in samples from 19 of 61 food-borne outbreaks evaluated. All food-borne outbreaks were due to enteropathogens. The prevalence of carriers in these outbreaks ranged from 4.4% to 66.6%. CONCLUSIONS: This widespread occurrence of ESBL-producing Enterobacteriaceae suggests that the community could act as a reservoir and that food could contribute to the spread of these strains.
Authors:
Raúl Jesús Mesa; Vanessa Blanc; Anicet R Blanch; Pilar Cortés; Juan José González; Susana Lavilla; Elisenda Miró; Maite Muniesa; Montserrat Saco; Ma Teresa Tórtola; Beatriz Mirelis; Pere Coll; Montserrat Llagostera; Guillem Prats; Ferran Navarro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-23
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  58     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-10     Completed Date:  2006-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  England    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Affiliation:
Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Agriculture
Animals
Anti-Bacterial Agents / pharmacology
Carrier State
Enterobacteriaceae / drug effects,  enzymology*,  isolation & purification*
Enterobacteriaceae Infections / epidemiology,  microbiology
Feces / microbiology
Food Microbiology*
Humans
Poultry / microbiology
Rabbits / microbiology
Seasons
Sewage / microbiology*
Spain / epidemiology
Swine / microbiology
beta-Lactam Resistance*
beta-Lactamases / metabolism*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Sewage; EC 3.5.2.6/beta-Lactamases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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