Document Detail

Extended regimens of the contraceptive vaginal ring: evaluation of clinical aspects.
MedLine Citation:
PMID:  20159178     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oral contraceptives used for extended periods of time have been extensively studied because of their potential benefits; however, there have been few publications on extended regimens of vaginal contraceptive rings. The aim of this study was to evaluate the clinical symptoms, body weight and blood pressure changes in women using the vaginal ring continuously over a 1-year period. STUDY DESIGN: This prospective cohort evaluated clinical aspects (dysmenorrhea, headache, breast tenderness, leg pain and irritability), body weight and blood pressure changes in 75 women (18-37 years of age) using a vaginal ring releasing 120 mcg of etonogestrel and 15 mcg of ethinyl estradiol daily, over a continuous period of 84 days, followed by a 7-day ring-free interval, during 1 year. The chi-square, Wilcoxon and paired t tests were used to analyze differences in the outcomes of interest. RESULTS: Compared to pre-enrollment status, at the end of the study period, the patients reported significantly less dysmenorrhea and irritability, a nonsignificant decrease in breast tenderness, leg pain and headaches. Blood pressure measurements remained unchanged. Although weight and body mass index increased significantly among users, they remained within the expected biological variation range. CONCLUSION: The vaginal ring used on an extended regimen is a well-tolerated contraceptive method and also offers noncontraceptive benefits.
Fernando Augusto Barreiros; Cristina Aparecida Falbo Guazzelli; Ricardo Barbosa; Francisco de Assis; F?bio Fernando de Ara?jo
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Publication Detail:
Type:  Journal Article     Date:  2009-11-14
Journal Detail:
Title:  Contraception     Volume:  81     ISSN:  1879-0518     ISO Abbreviation:  Contraception     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, Sao Paulo Federal University Family Planning Clinic/UNIFESP, S?o Paulo, Brazil.
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MeSH Terms
Chi-Square Distribution
Contraceptive Devices, Female / adverse effects*
Desogestrel / administration & dosage*,  adverse effects*
Drug Administration Schedule
Dysmenorrhea / drug therapy
Estrogens / administration & dosage,  adverse effects
Ethinyl Estradiol / administration & dosage*,  adverse effects*
Headache / chemically induced
Prospective Studies
Time Factors
Treatment Outcome
Weight Gain / physiology
Reg. No./Substance:
0/Estrogens; 54024-22-5/Desogestrel; 54048-10-1/3-keto-desogestrel; 57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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