Document Detail

Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
MedLine Citation:
PMID:  18706549     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the outcome of long letrozole therapy for induction of ovulation in patients with clomiphene-resistant polycystic ovary syndrome (PCOS). DESIGN: Prospective randomized controlled study. SETTING: University teaching hospital and a private practice. PATIENT(S): The study comprised 218 patients with clomiphene-resistant PCOS. INTERVENTION(S): Patients were randomly allocated to treatment with either long letrozole therapy (n = 108; 219 cycles) or short letrozole therapy (n = 110; 225 cycles). MAIN OUTCOME MEASURE(S): Number of growing and mature follicles, serum E(2) (pg/mL), serum P (ng/mL), endometrial thickness, occurrence of pregnancy and miscarriage. RESULT(S): The number of ovulating patients was greater in the long letrozole group (65.7% vs. 61.8%), but without statistical differences. The total numbers of follicles during stimulation was significantly greater in the long letrozole group (6.7 +/- 0.3 vs. 3.9 +/- 0.4). The numbers of follicles > or =14 mm and > or =18 mm were significantly greater in the long letrozole group. There was no significant difference in the pretreatment endometrial thickness or endometrial thickness at the time of hCG administration between the two groups. Pregnancy occurred in 28 of 225 cycles in the short group (12.4%) and 38 of 219 cycles (17.4%) in the long letrozole group, and the difference was statistically significant. CONCLUSION(S): The long letrozole protocol (10 days) can produce more mature follicles and subsequently more pregnancies than the short letrozole therapy (5 days).
Ahmed Badawy; Alaa Mosbah; Ayman Tharwat; Mohamed Eid
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-08-15
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  236-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Mansoura University Hospitals, Mansoura, Egypt.
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MeSH Terms
Anovulation / epidemiology
Aromatase Inhibitors / therapeutic use*
Clomiphene / therapeutic use*
Drug Resistance
Estrogen Antagonists / therapeutic use*
Hyperandrogenism / epidemiology
Nitriles / therapeutic use*
Ovarian Follicle / drug effects,  physiology,  physiopathology
Ovulation Induction / methods*
Polycystic Ovary Syndrome / drug therapy*
Pregnancy Outcome
Prospective Studies
Treatment Failure
Treatment Outcome
Triazoles / therapeutic use*
Young Adult
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Estrogen Antagonists; 0/Nitriles; 0/Triazoles; 112809-51-5/letrozole; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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