| Extended hepatectomy with segments I and VII as resection remnant: a simple model for small-for-size injuries in pigs. | |
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MedLine Citation:
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PMID: 19073405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Small-for-size (SFS) syndrome is an important clinical problem after living donor liver transplantation, split liver transplantation or extended hepatectomy. The uncertainty of the mechanisms and treatments of SFS syndrome urges surgeons to establish effective models for SFS syndrome. METHODS: A new porcine model for SFS syndrome based on extended hepatectomy was established. Portal pressure gradient was observed before and after the surgery, and venous sampling for estimation of alanine aminotransferase, total bilirubin, and international normalized ratio was continued on a daily basis. RESULTS: Although the external morphology of the porcine liver differs from that of human being, segmental anatomy is remarkably similar in term of its vascularity and biliary tree. Extended hepatectomy with segments I and VII as resection remnant (about 20% of total liver volume) resulted in similar survival rates, blood liver function tests, and elevated portal pressure gradient as clinical SFS syndrome. CONCLUSIONS: The extended hepatectomy based new model can easily be reproduced, with few costs and surgical complications. Clinical SFS syndrome can easily be simulated by this new model, which is a useful tool for studying SFS syndrome-related liver injuries, especially portal overperfusion and hypertension. |
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Authors:
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Qiang Xia; Tian-Fei Lu; Zhi-Hua Zhou; Ling-Xiang Hu; Jun Ying; De-Zhong Ding; Xiao-Song Chen; Jian-Jun Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepatobiliary & pancreatic diseases international : HBPD INT Volume: 7 ISSN: 1499-3872 ISO Abbreviation: HBPD INT Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101151457 Medline TA: Hepatobiliary Pancreat Dis Int Country: China |
Other Details:
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Languages: eng Pagination: 601-7 Citation Subset: IM |
Affiliation:
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Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China. xiaqiang@medmail.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Delayed Graft Function / physiopathology* Disease Models, Animal* Female Hepatectomy / methods* Hypertension, Portal / physiopathology Liver Function Tests Liver Transplantation / adverse effects*, methods Organ Size* Portal Pressure / physiology Survival Rate Sus scrofa* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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