Document Detail

Extended field radiation therapy in Hodgkin's disease: analysis of failures.
MedLine Citation:
PMID:  589558     Owner:  NLM     Status:  MEDLINE    
A retrospective analysis of 116 primary cases of stage I, II and III-A Hodgkin's disease demonstrated 27 failures, fourteen confirmed by biopsy. Twenty of the 27 (74%) were in lymph node areas only and seven had extranodal extensions. The most frequent site of failure was the hilar nodes and contiguous lung. The majority of failures (78%) occurred within 30 months of treatment and the cause of failure determined in 23 (85%), sixteen of which were due to technical errors of irradiation. Analysis of the dosimetry in the mediastinal, hilar nodes and contiguous lung failures revealed three factors which may have contributed to a low dose. These factors are: 1) the equivalent square, 2) off-axis beam diminution, and 3) the anteroposterior dose profile. Combined radiation therapy and chemotherapy was more effective than either modality alone in the treatment of these failures.
W B Mill; L A Palmer-Hanes; J A Purdy; T W Tillack; E H Reinhard; V Loeb; D N Parnell; M A Penkoske; K O Franssila
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer     Volume:  40     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2896-904     Citation Subset:  AIM; IM    
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MeSH Terms
Hodgkin Disease / pathology,  radiotherapy*
Lymph Nodes / pathology
Radiotherapy Dosage
Retrospective Studies

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