Document Detail

Extended daily dialysis in acute renal failure: a new therapeutic approach.
MedLine Citation:
PMID:  19363279     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Although intermittent hemodialysis (IHD) is the standard therapy in patients with acute renal failure, it is associated with several drawbacks. Extended daily dialysis (EDD) has been described as a compromise between IHD and continuous therapies and could potentially overcome problems associated with IHD. MATERIALS AND METHODS: We compared EDD with IHD each administered in 15 patients with acute renal failure. The IHD was administered 4 hours per session thrice weekly, while EDD was given for 8 hours per session daily with the same machines at similar blood and dialysate flow rates. Treatment outcome, metabolic control, and hemodynamic stability were assessed in the patients of each group. RESULTS: A total of 140 EDD treatment sessions and 82 IHD sessions were administered. Patients in the EDD and the IHD groups received a mean of 74.67 +/- 29.70 hours and 21.73 +/- 5.99 hours of dialysis, respectively (P < .001). The median urea reduction ratio in the EDD group was significantly higher (83.82% versus 64.66%, P < .001). Patients on EDD showed faster normalization of deranged metabolic parameters. Hemodynamically, EDD was better tolerated compared to IHD. The median predialysis mean arterial pressure in the EDD and IHD patients were 103.3 mm Hg and 100 mm Hg, respectively, while the postdialysis values were 78.6 mm Hg and 73 mm Hg, respectively. CONCLUSIONS: Extended daily dialysis appears to be a promising technique for dialysis in moderately ill patients having up to 2 organ failures.
Nirmal Kumar; Ravinder S Ahlawat
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Iranian journal of kidney diseases     Volume:  1     ISSN:  1735-8582     ISO Abbreviation:  Iran J Kidney Dis     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101316967     Medline TA:  Iran J Kidney Dis     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India.
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MeSH Terms
Blood Pressure
Hydrogen-Ion Concentration
Kidney Failure, Acute / blood,  physiopathology,  therapy*
Middle Aged
Potassium / blood
Renal Dialysis / methods*
Survival Analysis
Treatment Outcome
Urea / blood
Young Adult
Reg. No./Substance:
57-13-6/Urea; 7440-09-7/Potassium

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