Document Detail

Extended clomiphene citrate (CC) and prednisone for the treatment of chronic anovulation resistant to CC alone.
MedLine Citation:
PMID:  9093187     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate effectiveness and safety of a regimen of extended clomiphene citrate (CC) and prednisone for patients who fail treatment with CC alone. DESIGN: Retrospective observational analysis. SETTING: University-based tertiary infertility center. PATIENT(S): Twenty-four anovulatory patients who failed to ovulate after CC 150 mg administered for 5 days. INTERVENTION(S): Treatment consisted of CC given on cycle days 3 through 9 (extended) at a starting dose of 100 to 150 mg/d. Additionally, patients were given prednisone 5 mg orally each night throughout the cycle. MAIN OUTCOME MEASURE(S): Ovulation was confirmed by luteal serum P. Pregnancy was confirmed by rising hCG levels and transvaginal ultrasound. RESULT(S): A total of 60 cycles were available for review. Forty-four of these cycles were ovulatory (73%) and 11 patients (46%) conceived on this therapy. Logistic (two-parameter) pregnancy occurrence over time (cycles) revealed a maximum pregnancy probability of 0.66 and a cycle fecundity of 0.36. No complications of therapy were noted. CONCLUSION(S): Clomiphene citrate-resistant anovulatory patients have high rates of ovulation and pregnancy after treatment with extended CC and prednisone. This therapy offers a potential reduction in cost and risk and should be considered in this group of patients before gonadotropin stimulation or surgery.
J D Isaacs; S R Lincoln; B D Cowan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  67     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  641-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA. IVFDOC@FIONA.UMSMED.EDU
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MeSH Terms
Anovulation / drug therapy*
Chronic Disease
Clomiphene / administration & dosage,  pharmacology,  therapeutic use*
Drug Resistance
Drug Therapy, Combination
Fertility Agents, Female / administration & dosage,  pharmacology,  therapeutic use*
Glucocorticoids / administration & dosage,  pharmacology,  therapeutic use*
Logistic Models
Ovulation / drug effects,  physiology
Prednisone / administration & dosage,  pharmacology,  therapeutic use*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Fertility Agents, Female; 0/Glucocorticoids; 53-03-2/Prednisone; 911-45-5/Clomiphene
Comment In:
Fertil Steril. 1997 Oct;68(4):745-6   [PMID:  9341626 ]

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