Document Detail


Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data.
MedLine Citation:
PMID:  21538486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The combined toxic effects of Cd and Pb in the presence of different concentrations of Ca(2+) were predicted using the biotic ligand model (BLM), with the parameters derived from the Cd-only and Pb-only toxicity data. The BLM-based toxic unit (TU) approach and the proposed BLM-based f(mix) approach were used for prediction. The predicted mixture toxic effects using the BLM-based f(mix) approach were closer to the observed mixture effects (root mean square error [RMSE] = 9.7 at 25 mM Ca(2+) ) than that using the BLM-based TU approach (RMSE = 25.6 at 25 mM Ca(2+) ). This can be attributed to the fact that the BLM-based TU approach only considers the competition between Ca(2+) and Cd or Pb, whereas the BLM-based f(mix) approach considers both the competition between Cd and Pb and the competition between Ca(2+) and Cd or Pb for biotic ligand sites. In addition, the parameters derived from the Cd-only and Pb-only solutions in the presence of the background Ca(2+) concentration (0.025 mM) could be used to predict the mixture toxic effects at higher Ca(2+) concentrations. The BLM-based f(mix) approach proposed in the current study suggests a new way of predicting the Cd-Pb mixture toxicity from the single metal toxicity data by adopting the f(mix) values.
Authors:
Eun Hea Jho; Jinsung An; Kyoungphile Nam
Related Documents :
15574086 - Examination of the scaling of human jumping.
14997486 - Sweet substitute: a software tool for in silico fragmentation of peptide-linked n-glycans.
16528916 - Fishing for biomarkers: analyzing mass spectrometry data with the new clinprotools soft...
17262896 - Investigation into the factors affecting accuracy of mass measurements on a time-of-fli...
8635886 - Costs of major parasites to the australian livestock industries.
19228556 - Exploiting data topology in visualization and clustering of self-organizing maps.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-16
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  30     ISSN:  1552-8618     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-09-16     Revised Date:  2012-04-24    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1697-703     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 SETAC.
Affiliation:
Department of Civil and Environmental Engineering, Seoul National University, Gwanakgu, Seoul, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aliivibrio fischeri / drug effects
Cadmium / chemistry,  toxicity*
Calcium / chemistry
Dose-Response Relationship, Drug
Ecosystem
Lead / chemistry,  toxicity*
Ligands
Models, Biological
Models, Chemical*
Toxicity Tests / methods
Water Pollutants, Chemical / chemistry,  toxicity*
Chemical
Reg. No./Substance:
0/Ligands; 0/Water Pollutants, Chemical; 7439-92-1/Lead; 7440-43-9/Cadmium; 7440-70-2/Calcium
Comments/Corrections
Comment In:
Environ Toxicol Chem. 2012 Apr;31(4):689-90; author reply 690-2   [PMID:  22431136 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Calcium and magnesium enhance arsenate rhizotoxicity and uptake in Triticum aestivum.
Next Document:  Toxicity of metals to roots of cowpea in relation to their binding strength.