Document Detail

Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data.
MedLine Citation:
PMID:  21538486     Owner:  NLM     Status:  MEDLINE    
The combined toxic effects of Cd and Pb in the presence of different concentrations of Ca(2+) were predicted using the biotic ligand model (BLM), with the parameters derived from the Cd-only and Pb-only toxicity data. The BLM-based toxic unit (TU) approach and the proposed BLM-based f(mix) approach were used for prediction. The predicted mixture toxic effects using the BLM-based f(mix) approach were closer to the observed mixture effects (root mean square error [RMSE] = 9.7 at 25 mM Ca(2+) ) than that using the BLM-based TU approach (RMSE = 25.6 at 25 mM Ca(2+) ). This can be attributed to the fact that the BLM-based TU approach only considers the competition between Ca(2+) and Cd or Pb, whereas the BLM-based f(mix) approach considers both the competition between Cd and Pb and the competition between Ca(2+) and Cd or Pb for biotic ligand sites. In addition, the parameters derived from the Cd-only and Pb-only solutions in the presence of the background Ca(2+) concentration (0.025 mM) could be used to predict the mixture toxic effects at higher Ca(2+) concentrations. The BLM-based f(mix) approach proposed in the current study suggests a new way of predicting the Cd-Pb mixture toxicity from the single metal toxicity data by adopting the f(mix) values.
Eun Hea Jho; Jinsung An; Kyoungphile Nam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-16
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  30     ISSN:  1552-8618     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-09-16     Revised Date:  2012-04-24    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1697-703     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 SETAC.
Department of Civil and Environmental Engineering, Seoul National University, Gwanakgu, Seoul, Republic of Korea.
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MeSH Terms
Aliivibrio fischeri / drug effects
Cadmium / chemistry,  toxicity*
Calcium / chemistry
Dose-Response Relationship, Drug
Lead / chemistry,  toxicity*
Models, Biological
Models, Chemical*
Toxicity Tests / methods
Water Pollutants, Chemical / chemistry,  toxicity*
Reg. No./Substance:
0/Ligands; 0/Water Pollutants, Chemical; 7439-92-1/Lead; 7440-43-9/Cadmium; 7440-70-2/Calcium
Comment In:
Environ Toxicol Chem. 2012 Apr;31(4):689-90; author reply 690-2   [PMID:  22431136 ]

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