Document Detail

Extended acute toxicity study of (188) Re-liposome in Rats.
MedLine Citation:
PMID:  22535684     Owner:  NLM     Status:  Publisher    
Liposomes can selectively target cancer sites and carry payloads, thereby improving diagnostic and therapeutic effectiveness as well as reducing toxicity. To evaluate therapeutic strategies, it is essential to use animal models reflecting important safety aspects before clinical application. As our previous study found that a high dosage (185 of MBq) of (188) Re-N,N-bis (2-mercaptoethyl)-N',N'-diethylethylenediamine-labeled pegylated liposomes ((188) Re-liposome) induced a decrease in white blood cell (WBC) count in Sprague-Dawley rats 7 days postinjection, the objective of the present study was to investigate extended acute radiotoxicity of (188) Re-liposome. Rats were administered via intravenous (i.v.) injection with (188) Re-liposome (185, 55.5 and 18.5 MBq), normal saline as a blank control or non-radioactive liposome as a vehicle control. Mortality, clinical signs, food consumption, body weights, urinary, biochemical and hematological analyzes were examined. In addition, gross necropsy and histopathological examinations were also performed at the end of the follow-up period. None of the rats died and no clinical sign was observed during the 28-day study period. Only male rats receiving (188) Re-liposome at a high dosage (185 MBq) displayed a slight weight loss compared with the control rats. In both male and female rats, the WBC counts of both high-dose and medium-dose (55.5 MBq) groups reduced significantly 7 days postinjection, but recovered to the normal range on Study Day 29. There was no significant difference in urinary analyzes, biochemical parameters and histopathological assessments between the (188) Re-liposome-treated and control groups. The information generated from the present study on extended acute toxicity of (188) Re-liposome will serve as a safety reference for radiopharmaceuticals in early-phase clinical trials. Copyright © 2012 John Wiley & Sons, Ltd.
Liu Chi-Mou; Tsai Chia-Che; Yu Chia-Yu; Lee Wan-Chi; Ho Chung-Li; Chang Tsui-Jung; Chang Chih-Hsien; Lee Te-Wei
Related Documents :
16154604 - Two distinctive apomorphine-induced phenotypes in the roman high- and low-avoidance rats.
9497024 - Effects of dopamine agonists and antagonists on pcp-induced stereotyped behaviour and s...
300884 - Self-stimulation of the mfb or vta after microinjection of haloperidol into the prefron...
570724 - Enduring changes in dopamine receptor cells of pups from drug administration to pregnan...
7986384 - Attenuated release of atrial natriuretic peptide and vasorelaxation in streptozotocin-i...
16403784 - Methamphetamine-induced dopaminergic neurotoxicity is regulated by quinone-formation-re...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-26
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  -     ISSN:  1099-1263     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Institute of Nuclear Energy Research, Taoyuan, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  4D blood flow visualization fusing 3D and 4D MRA image sequences.
Next Document:  Increment of hematopoietic progenitor cell count as an indicator of efficient autologs stem cell har...