Document Detail

Expressions of cyclin E2 and survivin in acute leukemia and their correlation.
MedLine Citation:
PMID:  16638210     Owner:  NLM     Status:  MEDLINE    
Cyclin E2 is present in solid tumors, while its expression and clinical value in acute leukemia is unknown. This study was aimed to investigate the expression of cyclin E2 and survivin gene in bone marrow cells from patients with acute leukemia and their relationship. Reverse transcription polymerase chain reaction was used for detection of the expression of cyclin E2 and survivin mRNA in 84 adult patients with acute leukemia which included 16 cases of relapse, 60 cases of de novo acute leukemia, 8 cases of continuously complete remission, and 20 normal persons as controls. The results showed that (1) positive expression of cyclin E2 (70.24%) in acute leukemia patients was significantly higher than that (0%) in controls, positive expression of survivin (72.62%) in acute leukemia patients was higher than that (30%) in control. (2) the expression of cyclin E2 positively correlated with that of survivin in acute leukemia patients. (3) remission rate in cyclin E2-positive patients (55.81%) was lower than that (88.24%) in cyclin E2-negative patients, the rate of cyclin E2 expression in relapse group was the highest among the three groups; while that in continuously complete remission group was the lowest among the three groups. (4) positive rate of cyclin E2 expression (59.32%) in patients with acute myelocytic leukemia was lower than that (96%) in patients with acute lymphocytic leukemia, no correlation between cyclin E2 expression and white blood cell counts of patients was found. It is concluded that the overexpression of cyclin E2 has been confirmed for the first time to positively correlate with the expression of the survivin in acute leukemia patients, and implicate the poor prognosis. Cyclin E2 may be used as a marker for examination of minimal residual disease.
Ying Wang; Shi-Rong Xu; Feng-Ru Lin; Xiao-Nan Guo; Jin-Hai Ren
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology     Volume:  14     ISSN:  1009-2137     ISO Abbreviation:  Zhongguo Shi Yan Xue Ye Xue Za Zhi     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-26     Completed Date:  2007-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101084424     Medline TA:  Zhongguo Shi Yan Xue Ye Xue Za Zhi     Country:  China    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Institute of Hematology, Department of Hematology, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, China.
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MeSH Terms
Acute Disease
Cyclin E / biosynthesis*,  genetics
Leukemia / metabolism*
Leukemia, Myeloid, Acute / metabolism
Microtubule-Associated Proteins / biosynthesis*,  genetics
Middle Aged
Neoplasm Proteins / biosynthesis*,  genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
RNA, Messenger / biosynthesis,  genetics
Reg. No./Substance:
0/BIRC5 protein, human; 0/Cyclin E; 0/Microtubule-Associated Proteins; 0/Neoplasm Proteins; 0/RNA, Messenger

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