Document Detail


Expression of the zebrafish gene hlx-1 in the prechordal plate and during CNS development.
MedLine Citation:
PMID:  7907015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The zebrafish hlx-1 gene belongs to the H2.0 subfamily of homeobox genes and is closely related to the mouse Dbx gene with respect to both homeodomain homology (96.7%) and neural expression during embryogenesis. Analysis of hlx-1 expression by in situ hybridization reveals several particularly interesting features. In late gastrula embryos, hlx-1 transcripts are detected within a circular area in the region of the presumptive rostral brain. Subsequently, the expression domain becomes restricted to the hypoblast and undergoes dynamic changes involving conversion into a longitudinal stripe which elongates and retracts following a temporal sequence. The site of transient hlx-1 expression along the ventral midline of the rostral neurectoderm, which in part corresponds to the prechordal plate, suggests a role in the determination of head mesoderm as well as in patterning of the rostral brain. As the midline stripe gradually disappears, the hlx-1 gene becomes regionally expressed within the diencephalon and at a specific dorsoventral level along the hindbrain and spinal cord. In the hindbrain, expression is initiated in dorsoventrally restricted transversal stripes which correlate with the segmental pattern of rhombomeres. The stripes fuse into bilateral columns that are later converted to two series of paired transversal stripes at the rhombomere borders. This pattern is consistent with the proposed subdivision of hindbrain segments into rhombomere centers separated by border regions.
Authors:
A Fjose; J C Izpisúa-Belmonte; C Fromental-Ramain; D Duboule
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  120     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-04     Completed Date:  1994-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  71-81     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, University of Bergen, Norway.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Central Nervous System / embryology*
Chick Embryo
Drosophila
Gastrula / physiology*
Gene Expression*
Genes, Homeobox / genetics*
Immunohistochemistry
In Situ Hybridization
Mice
Molecular Sequence Data
Rhombencephalon / embryology
Sequence Homology, Amino Acid
Spinal Cord / embryology
Zebrafish / embryology,  genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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