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Expression of voltage-gated calcium channel α(2) δ(4) subunits in the mouse and rat retina.
MedLine Citation:
PMID:  23296739     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Highvoltage-activated Ca channels participate in multiple cellular functions, including transmitter release, excitation, and gene transcription. Ca channels are heteromeric proteins consisting of a pore-forming α(1) subunit andauxiliary α(2) δ and β subunits. Although there are reports of α(2) δ(4) subunit mRNA in the mouse retina and the localization of the α(2) δ(4) subunit immunoreactivity to salamander photoreceptor terminals, there is a limited overall understanding of itsexpression and localization in the retina. α(2) δ(4) subunitexpression and distribution in the mouse and ratretina were evaluated using RT-PCR, Western blot and immunohistochemistry with specific primers and awell-characterizedantibody to theα(2) δ(4) subunit.α(2) δ(4) subunit mRNA and protein are present in mouse and rat retina, brain, and liver homogenates. Immunostaining for the α(2) δ(4) subunit is mainly localized toMüller cell processes and endfeet, photoreceptor terminals and photoreceptor outer segments. This subunit is also expressed in a fewdisplaced ganglion cells and bipolar cell dendrites. These findings suggest that the α(2) δ(4) subunit participates in the modulation of L-typeCa(2+) current regulating neurotransmitter release from photoreceptor terminals and Ca(2+) -dependent signaling pathwaysin bipolar and Müller cells. J. Comp. Neurol., 2013. © 2013 Wiley Periodicals, Inc.
Authors:
Luis Pérez de Sevilla Müller; Janelle Liu; Alexander Solomon; Allen Rodriguez; Nicholasc Brecha
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  -     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Departments of Neurobiology and Geffen School of Medicine at Los Angeles, University of California. luisperez@mednet.ucla.edu.
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