| Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse. | |
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MedLine Citation:
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PMID: 11684349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The El mouse is an animal model for hereditary epilepsy. It undergoes a convulsive seizure lasting 10-30 s after vestibular stimulation, such as "tossing-up". To better characterize the effects of seizure activity in the El mouse, we examined the expression profile of vesl-1S/homer-1a mRNA in the brain. It has been shown that this mRNA is expressed after long-term potentiation or seizures induced by electrical or pharmacological stimulations. The basal level of vesl-1S mRNA was very low even in seizure-susceptible El mice. The El mouse hippocampus, but not that of ddY mice, showed a remarkable increase in vesl-1S mRNA expression in the dentate granule cell layer after seizure induced by "tossing-up". The mRNA remained for about 3 h after the seizure and disappeared after 8 h. |
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Authors:
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R Morioka; A Kato; Y Fueta; H Sugiyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 313 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-30 Completed Date: 2001-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 99-101 Citation Subset: IM |
Affiliation:
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Department of Biology, Faculty of Science, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Chemistry / genetics* Carrier Proteins / genetics* Epilepsy / genetics*, physiopathology Female Gene Expression Genes, Immediate-Early / physiology Hippocampus / physiopathology In Situ Hybridization Long-Term Potentiation / genetics* Mice Mice, Mutant Strains Neuropeptides / genetics* RNA, Messenger / analysis |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Homer protein; 0/Neuropeptides; 0/RNA, Messenger |
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