Document Detail

Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse.
MedLine Citation:
PMID:  11684349     Owner:  NLM     Status:  MEDLINE    
The El mouse is an animal model for hereditary epilepsy. It undergoes a convulsive seizure lasting 10-30 s after vestibular stimulation, such as "tossing-up". To better characterize the effects of seizure activity in the El mouse, we examined the expression profile of vesl-1S/homer-1a mRNA in the brain. It has been shown that this mRNA is expressed after long-term potentiation or seizures induced by electrical or pharmacological stimulations. The basal level of vesl-1S mRNA was very low even in seizure-susceptible El mice. The El mouse hippocampus, but not that of ddY mice, showed a remarkable increase in vesl-1S mRNA expression in the dentate granule cell layer after seizure induced by "tossing-up". The mRNA remained for about 3 h after the seizure and disappeared after 8 h.
R Morioka; A Kato; Y Fueta; H Sugiyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  313     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2001-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Department of Biology, Faculty of Science, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
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MeSH Terms
Brain Chemistry / genetics*
Carrier Proteins / genetics*
Epilepsy / genetics*,  physiopathology
Gene Expression
Genes, Immediate-Early / physiology
Hippocampus / physiopathology
In Situ Hybridization
Long-Term Potentiation / genetics*
Mice, Mutant Strains
Neuropeptides / genetics*
RNA, Messenger / analysis
Reg. No./Substance:
0/Carrier Proteins; 0/Homer protein; 0/Neuropeptides; 0/RNA, Messenger

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