Document Detail

Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients.
MedLine Citation:
PMID:  17201239     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vascular endothelial growth factor (VEGF) is a potent proangiogenic cytokine, and it also increases vascular permeability. It is well known that VEGF levels are increased in the airway of asthmatic patients. Hypoxia-inducible factor (HIF) induces a rapid and strong increase in VEGF expression. OBJECTIVES: To evaluate the relationship between VEGF level and clinical characteristics and to determine whether VEGF expression is associated with HIF expression in asthmatic patients. METHODS: Bronchoscopy was performed on 30 asthmatic patients and 14 control subjects. The concentration of VEGF in the bronchoalveolar lavage fluid (BALF) was examined using enzyme-linked immunosorbent assay. We measured VEGF, HIF-1alpha, and HIF-2alpha expression on biopsy specimens by means of immunoreactivity. RESULTS: The VEGF level in the BALF was significantly higher in asthmatic patients than in controls. The VEGF level correlated with eosinophil counts in the BALF in asthmatic subjects (r = 0.501; P < .01). However, the VEGF level did not correlate with percentage of forced expiratory volume in 1 second and airway hyperresponsiveness. Asthmatic patients exhibited higher VEGF, HIF-1alpha, and HIF-2alpha immunoreactivity in the submucosa than did controls. Furthermore, VEGF expression correlated significantly with HIF-1alpha (r = 0.614; P = .02) and HIF-2alpha (r = 0.881; P = .001) expression. CONCLUSION: These findings suggest that VEGF may play an important role in inflammation and that VEGF level is related to HIF in bronchial asthma.
Sook Young Lee; Soon Kwon; Kwan Hyoung Kim; Hwa Sik Moon; Jung Sup Song; Sung Hak Park; Young Kyoon Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  97     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-01-04     Completed Date:  2007-01-16     Revised Date:  2007-04-11    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  794-9     Citation Subset:  IM    
Department of Internal Medicine, Kangnam St Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
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MeSH Terms
Asthma / blood,  metabolism*
Basic Helix-Loop-Helix Transcription Factors / metabolism*
Bronchoalveolar Lavage Fluid / chemistry,  cytology
Case-Control Studies
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
Leukocyte Count
Respiratory Mucosa / metabolism
Vascular Endothelial Growth Factor A / metabolism*
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Vascular Endothelial Growth Factor A; 0/endothelial PAS domain-containing protein 1

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