Document Detail


Expression of ubiquitin in peripheral inflammatory cells from patients with coronary artery disease.
MedLine Citation:
PMID:  19094431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to its role in the removal of damaged and unneeded proteins, the ubiquitin-proteasome system (UPS) may play a key role in coronary artery disease (CAD). To investigate the expression of ubiquitin in monocytes and lymphocytes isolated from patients at different stages of CAD, 120 patients with CAD (40 with acute myocardial infarction [AMI], 40 with unstable angina pectoris [UAP] and 40 with stable angina pectoris [SAP]) were selected; 40 patients with normal coronary arteries served as controls. At both the mRNA and protein levels, ubiquitin expression was higher in patients with CAD than in controls, and patients with AMI had a much higher expression of ubiquitin (at both the mRNA and protein levels) than those with SAP and UAP. These data indicate that ubiquitin expression increased with increasing severity of CAD, suggesting that ubiquitin may play a critical role in the development and progression of CAD.
Authors:
S-M Chen; H-X Zhang; Y-G Li; D-M Wang; G-H Zhang; C-J Tan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  36     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1227-34     Citation Subset:  IM    
Affiliation:
Department of Cardiology, The First Affiliated Hospital, Medical College, Shantou University, Shantou Guangdong, China.
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MeSH Terms
Descriptor/Qualifier:
Angina, Unstable / blood*,  genetics
Coronary Artery Disease / blood*,  genetics
Female
Gene Expression
Humans
Lymphocytes / metabolism*
Male
Middle Aged
Monocytes / metabolism*
Myocardial Infarction / blood*,  genetics
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Ubiquitin / blood*,  genetics
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Ubiquitin

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