| Expression of ubiquitin in peripheral inflammatory cells from patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 19094431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to its role in the removal of damaged and unneeded proteins, the ubiquitin-proteasome system (UPS) may play a key role in coronary artery disease (CAD). To investigate the expression of ubiquitin in monocytes and lymphocytes isolated from patients at different stages of CAD, 120 patients with CAD (40 with acute myocardial infarction [AMI], 40 with unstable angina pectoris [UAP] and 40 with stable angina pectoris [SAP]) were selected; 40 patients with normal coronary arteries served as controls. At both the mRNA and protein levels, ubiquitin expression was higher in patients with CAD than in controls, and patients with AMI had a much higher expression of ubiquitin (at both the mRNA and protein levels) than those with SAP and UAP. These data indicate that ubiquitin expression increased with increasing severity of CAD, suggesting that ubiquitin may play a critical role in the development and progression of CAD. |
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Authors:
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S-M Chen; H-X Zhang; Y-G Li; D-M Wang; G-H Zhang; C-J Tan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of international medical research Volume: 36 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-02-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
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Languages: eng Pagination: 1227-34 Citation Subset: IM |
Affiliation:
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Department of Cardiology, The First Affiliated Hospital, Medical College, Shantou University, Shantou Guangdong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina, Unstable
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blood*,
genetics Coronary Artery Disease / blood*, genetics Female Gene Expression Humans Lymphocytes / metabolism* Male Middle Aged Monocytes / metabolism* Myocardial Infarction / blood*, genetics RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Ubiquitin / blood*, genetics |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Ubiquitin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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