Document Detail


Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis.
MedLine Citation:
PMID:  21079983     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Our study is to investigate whether tyrosine kinase receptor B (TrkB) is expressed in eutopic endometrium of women with adenomyosis and its association with clinical characteristics. METHODS: We collected endometrial tissues from 31 women with adenomyosis and 30 adenomyosis-free women undergoing surgery for benign indications. TrkB expression was assessed by immunohistochemistry and reverse-transcription polymerase chain reaction. RESULTS: Immunoreactive staining for TrkB was present as brown flocculent precipitate in the endometrial cells. The average level of TrkB protein (quantitation of immunostaining intensity) in secretory endometrial samples of women with adenomyosis was significantly higher than that in controls (p < 0.01). The average level of TrkB messenger RNA (mRNA) expression of women with adenomyosis was significantly higher than that of controls at secretory phase (p < 0.01). In addition, the immunostaining quantitation of TrkB protein was positively correlated with the serum CA125 (r = 0.308, p = 0.016) and dysmenorrhea (r = 0.393, p = 0.002). CONCLUSIONS: Our study revealed elevation of TrkB protein and mRNA expression in the secretory endometrium of women with adenomyosis. Moreover, TrkB protein expression in human endometrium was positively correlated with the serum CA125 and dysmenorrhea. TrkB might contribute to the pathogenesis and progression of adenomyosis.
Authors:
Yaqin Huang; Wei Zheng; Lin Mu; Yuefang Ren; Xuejun Chen; Fang Liu
Related Documents :
8866003 - Okadaic acid increases fibronectin synthesis in mc3t3-e1 cells.
16179803 - Effect of inhibition of farnesylation and geranylgeranylation on renal fibrogenesis in ...
9142213 - Altered transcriptional regulation of the insulin-like growth factor 2 gene in human he...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-16
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  -     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88, Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transvaginal ultrasound of cervical length and its correlation to digital cervical examination, time...
Next Document:  Ectopic olfactory neuroblastoma: report of four cases and a review of the literature.