| Expression of a two-pore domain K+ channel (TASK-1) in developing avian and mouse ventricular conduction systems. | |
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MedLine Citation:
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PMID: 16145663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we report the identification and amino acid sequence of a novel two-pore domain potassium channel (TASK-1) in chicken. This protein, cTASK-1, is highly similar to mouse and human TASK-1 particularly within the pore regions. We describe the expression profile of both chicken and mouse TASK-1 in the embryonic heart as the ventricular conduction system develops. The developmental distribution of TASK-1 is similar in chicken and mouse. Initially, TASK-1 is expressed throughout the myocardium of the early heart tube. However, as cardiogenesis proceeds, ventricular expression becomes restricted to the trabeculated myocardium and eventually the bundle of His, bundle branches, and Purkinje fibers of the mature conduction system. This finding suggests that components of the ventricular conduction system differentiate from TASK-1-positive myocytes of the early heart tube that retain TASK-1 expression as they mature. Our results are consistent with a common mechanism for ventricular conduction system development in avians and mammals, despite differences in the anatomy of the mature conduction systems of these organisms. |
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Authors:
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Victoria Graham; Hengtao Zhang; Shannon Willis; Tony L Creazzo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 235 ISSN: 1058-8388 ISO Abbreviation: Dev. Dyn. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-14 Completed Date: 2006-03-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 143-51 Citation Subset: IM |
Copyright Information:
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2005 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics/Neonatology, Neonatal/Perinatal Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Chick Embryo Heart Conduction System / embryology*, metabolism*, physiology Heart Ventricles / embryology, metabolism Mice Molecular Sequence Data Nerve Tissue Proteins / biosynthesis, genetics* Potassium Channels, Tandem Pore Domain / biosynthesis, genetics* Ventricular Function |
| Grant Support | |
ID/Acronym/Agency:
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HL36059/HL/NHLBI NIH HHS; HL71015/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nerve Tissue Proteins; 0/Potassium Channels, Tandem Pore Domain; 0/potassium channel subfamily K member 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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