| Expression of tubulin beta II in neuroepithelial tumors: reflection of architectural changes in the developing human brain. | |
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MedLine Citation:
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PMID: 15983829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tubulin beta II (Tub-II) is widely distributed in the developing neuronal axons and dendrites. Recent studies have demonstrated that Tub-II is also important in the early development of the human brain, and Tub-II represents a marker for progenitor and neural stem cells. To elucidate the correlation between the developing brain and neuroepithelial tumors (NETs), the present study assessed Tub-II expression by NETs and normal brain tissue using immunohistochemical and immunoblot analyses. In the gliomas, decreased numbers and staining intensities of Tub-II-positive cells tended to be associated with increased differentiation. Conversely, neuronal neoplasms displayed high percentages and strong staining intensities among the Tub-II-positive cells, irrespective of differentiation. In neuronal neoplasms and neoplasms with neuronal differentiation, Tub-II staining was far more intense and more homogeneous than Tub-II staining in gliomas. These results indicate that the expression of Tub-II in NETs may reflect architectural changes in the developing brain and may support the hypothesis that neuroepithelial tumors originate from glioneuronal progenitor cells capable of generating astrocytic, and neuronal cell types. |
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Authors:
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Yasuo Sugita; Yasuhiro Nakamura; Munehiko Yamamoto; Eriko Oda; Osamu Tokunaga; Minoru Shigemori |
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Publication Detail:
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Type: Journal Article Date: 2005-06-28 |
Journal Detail:
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Title: Acta neuropathologica Volume: 110 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-31 Completed Date: 2005-12-13 Revised Date: 2007-11-09 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 127-34 Citation Subset: IM |
Affiliation:
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Department of Pathology and Biodefense, Saga Medical School, Nabeshima 5-1-1, 849-8501, Saga, Japan. sugitaoy@post.saga-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Western Brain / embryology*, metabolism*, pathology Brain Neoplasms / metabolism* Cell Differentiation / physiology Cell Lineage / physiology Fetus Humans Immunohistochemistry Infant Neurons / cytology, metabolism, pathology Stem Cells / cytology, physiology Tubulin / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Tubulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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