| Expression of tetraspanins in peripheral blood leukocytes: a comparison between normal and infectious conditions. | |
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MedLine Citation:
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PMID: 15304003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of tetraspanins is undefined, despite their detection in diverse cell types and functions. This study addresses the characterization of tetraspanin expression levels in normal peripheral blood leukocytes (PBL) and in patients with bacterial infection. Membranal and cytoplasmic expression of CD9, CD53, CD63, CD81, CD82 and CD151 in polymorphonuclears (PMN), monocytes, B and T lymphocytes was assessed using flow cytometry. Results suggested that for normal PBL, PMN are distinguished by dominant cytoplasmic CD63; monocytes and B cells prevailingly express CD53; CD82 is primarily expressed on T-cell membranes. However, a major trend of downregulation was demonstrated for the examined tetraspanins, except CD63, in all patients' PBL subtypes. Therefore, tetraspanin modulation in infections may be attributed to elevated leukocyte motility in immune reactions and this is compatible with the previous publications of tetraspanins as metastasis suppressors. This work represents the first comprehensive baseline of tetraspanin expression in normal PBL and in infectious disorders. |
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Authors:
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T Tohami; L Drucker; J Radnay; H Shapira; M Lishner |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 64 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-12 Completed Date: 2005-03-07 Revised Date: 2010-10-20 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 235-42 Citation Subset: IM |
Affiliation:
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Oncogenetic Laboratory, Sapir Medical Center, Meir Hospital, Kfar Saba, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antigens, CD / genetics* Antigens, Differentiation, T-Lymphocyte / genetics Gene Expression / immunology Humans Kangai-1 Protein Leukocytes / physiology* Membrane Glycoproteins / genetics* Middle Aged Platelet Membrane Glycoproteins / genetics Pneumonia / immunology, physiopathology* Proto-Oncogene Proteins / genetics Urinary Tract Infections / immunology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, T-Lymphocyte; 0/CD151 antigen; 0/CD53 antigen; 0/CD63 antigen; 0/CD81 antigen; 0/CD82 protein, human; 0/CD9 antigen; 0/Kangai-1 Protein; 0/Membrane Glycoproteins; 0/Platelet Membrane Glycoproteins; 0/Proto-Oncogene Proteins |
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