Document Detail


Expression of synaptic and phototransduction markers during photoreceptor development in the marmoset monkey Callithrix jacchus.
MedLine Citation:
PMID:  19003975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marmoset photoreceptor development was studied to determine the expression sequence for synaptic, opsin, and phototransduction proteins. All markers appear first in cones within the incipient foveal center or in rods at the foveal edge. Recoverin appears in cones across 70% of the retina at fetal day (Fd) 88, indicating that it is expressed shortly after photoreceptors are generated. Synaptic markers synaptophysin, SV2, glutamate vesicular transporter 1, and CTBP2 label foveal cones at Fd 88 and cones at the retinal edge around birth. Cones and rods have distinctly different patterns of synaptic protein and opsin expression. Synaptic markers are expressed first in cones, with a considerable delay before they appear in rods at the same eccentricity. Cones express synaptic markers 2-3 weeks before they express opsin, but rods express opsin 2-4 weeks before rod synaptic marker labeling is detected. Medium/long-wavelength-selective (M&L) opsin appears in foveal cones and rod opsin in rods around the fovea at Fd 100. Very few cones expressing short-wavelength-selective (S) opsin are found in the Fd 105 fovea. Across peripheral retina, opsin appears first in rods, followed about 1 week later by M&L cone opsin. S cone opsin appears last, and all opsins reach the retinal edge by 1 week after birth. Cone transducin and rod arrestin are expressed concurrently with opsin, but cone arrestin appears slightly later. Marmoset photoreceptor development differs from that in Macaca and humans. It starts relatively late, at 56% gestation, compared with Macaca at 32% gestation. The marmoset opsin expression sequence is also different from that of either Macaca or human.
Authors:
Anita Hendrickson; David Troilo; Hidayat Djajadi; Daniel Possin; Alan Springer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  512     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-01-15     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  218-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / metabolism*
Callithrix / anatomy & histology,  physiology*
Eye Proteins / metabolism*
Humans
Light Signal Transduction / physiology*
Macaca
Opsins / metabolism
Photoreceptor Cells / cytology,  physiology*
Recoverin / metabolism
Synapses / chemistry,  metabolism*
Grant Support
ID/Acronym/Agency:
EY01730/EY/NEI NIH HHS; EY11228/EY/NEI NIH HHS; P51-RR13986/RR/NCRR NIH HHS; P51RR000167/RR/NCRR NIH HHS; R01 EY011228/EY/NEI NIH HHS; R01 EY011228-11/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Eye Proteins; 0/Opsins; 135844-11-0/Recoverin
Comments/Corrections

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