Document Detail

Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei--infected mouse macrophages requires bacterial internalization.
MedLine Citation:
PMID:  17240114     Owner:  NLM     Status:  MEDLINE    
We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators was most probably triggered from within rather than at the cell surface of mouse macrophage cell line (RAW264.7) suggesting that macrophage activation most likely requires the interaction of bacteria with a putative host cell cytoplasmic component(s).
P Ekchariyawat; S Pudla; K Limposuwan; S Arjcharoen; S Sirisinha; P Utaisincharoen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-19
Journal Detail:
Title:  Microbial pathogenesis     Volume:  42     ISSN:  0882-4010     ISO Abbreviation:  Microb. Pathog.     Publication Date:    2007 Feb-Mar
Date Detail:
Created Date:  2007-02-27     Completed Date:  2007-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606191     Medline TA:  Microb Pathog     Country:  England    
Other Details:
Languages:  eng     Pagination:  104-10     Citation Subset:  IM    
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
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MeSH Terms
Burkholderia pseudomallei / physiology*
Cell Line
Macrophages / metabolism,  microbiology
Melioidosis / metabolism*,  microbiology
Signal Transduction*
Suppressor of Cytokine Signaling Proteins / metabolism*
Reg. No./Substance:
0/Socs3 protein, mouse; 0/Suppressor of Cytokine Signaling Proteins; 0/cytokine inducible SH2-containing protein

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