Document Detail


Expression of somatostatin receptor SST4 in human placenta and absence of octreotide effect on human placental growth hormone concentration during pregnancy.
MedLine Citation:
PMID:  9360539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In pregnancy, the human placenta GH acts as a growth-promoting hormone and appears to be the main stimulator of insulin-like growth factor I (IGF-I) secretion. In a woman with a TSH-secreting macroadenoma, successful treatment with the somatostatin analog octreotide was conducted during the first month and the second half of pregnancy without side-effects on placental and fetal development. As observed in normal pregnancy, both serum placental GH and IGF-I levels increased throughout pregnancy and dropped sharply after delivery. In placental membranes from both treated and healthy untreated patients, we demonstrated the presence of high affinity binding sites for somatostatin-14 (Kd, 4.6 and 5.3 nmol/L; binding capacity, 1.53 and 1.35 pmol/mg protein, respectively). These receptors displayed low affinity for octreotide (IC50, 1.2-2 mumol/L), suggesting the presence of SST1 and/or SST4 receptors. We found that messenger ribonucleic acids of these two subtypes were expressed in both human placental tissue and purified human cytotrophoblast cells. Finally, the SST1-selective analog, des-AA1,2,5[D-Trp8,IAmp9]S-14 had low affinity for placental somatostatin receptors. These results argue in favor of the presence of the SST4 subtype in human placenta. At the doses administered, octreotide did not bind to placental somatostatin receptors. Our results may explain the absence of changes in both human placental GH and IGF-I concentrations that we observed during octreotide treatment.
Authors:
P Caron; L Buscail; A Beckers; J P Estève; A Igout; G Hennen; C Susini
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  82     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-11-25     Completed Date:  1997-11-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3771-6     Citation Subset:  AIM; IM    
Affiliation:
Service d'Endocrinologie et Maladies Métaboliques, Institut Louis Bugnard, Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / drug therapy,  secretion
Adult
Cell Membrane / metabolism
Female
Gene Expression
Human Growth Hormone / metabolism*
Humans
Insulin-Like Growth Factor I / metabolism
Octreotide / adverse effects*,  therapeutic use
Pituitary Neoplasms / drug therapy*,  secretion
Placenta / drug effects,  metabolism*
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy*
Receptors, Somatostatin / genetics*,  metabolism
Somatostatin / metabolism
Thyrotropin / secretion
Chemical
Reg. No./Substance:
0/Receptors, Somatostatin; 12629-01-5/Human Growth Hormone; 51110-01-1/Somatostatin; 67763-96-6/Insulin-Like Growth Factor I; 83150-76-9/Octreotide; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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