| Expression and significance of TGF-beta1/Smad signaling pathway in children with IgA nephropathy. | |
| | |
MedLine Citation:
|
PMID: 19693466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: IgA nephropathy (IgAN) exhibits an indolent but slowly progressive course, and about 30% of children with IgAN are found to deteriorate to end-stage renal failure characterized by overaccumulation of extracellular matrix, diffuse glomerular sclerosis, and tubulointerstitial fibrosis. The TGF-beta/Smad signaling pathway plays an important role in glomerulosclerosis and tubulointerstitial fibrosis. The present study aimed to elucidate the significance of expressions of TGF-beta1, phosphorylated Smad3 (p-Smad3), Smad7 and fibronectin (FN) in the renal tissue of children with IgAN. METHODS: Forty-six children with IgAN were divided into 3 groups according to their clinical features: isolated hematuria group (IH group, 8 patients), hematuria and proteinuria group (HP group, 24), and nephritic syndrome group (NS group, 14). Patients were also divided into three groups according to their pathologic grade: grade I+II (22 patients), grade III (12) and grade IV (12) groups. Five normal renal specimens were used as the control group. The expression of TGF-beta1, p-Smad3, Smad7 and FN in renal biopsy specimens was detected by two-step PowerVision. The degrees of renal tubular injury and interstitial fibrosis were scored according to the Katafuchi semi-quantitative criteria. RESULTS: The expression of TGF-beta1, p-Smad3, Smad7 and FN in children with IgAN was significantly higher than that in the control group (in glomeruli: P<0.05, P<0.01, P<0.05 and P<0.01, respectively; in tubulointerstitium: P<0.05, P<0.05, P<0.01 and P<0.05, respectively) and the highest expression levels were found in the NS and grade IV groups (P<0.05, P<0.01). The expression levels of the four proteins were not only positvely correlated with each other, but also with the grade of renal tubular injury and renal interstitial fibrosis (P<0.05). CONCLUSION: The TGF-beta1/Smad signaling pathway plays an important role in the progress of glomerular sclerosis, renal tubular injury and interstitial fibrosis in children with IgAN. |
| | |
Authors:
|
Wei Wu; Xiao-Yun Jiang; Qiao-Ling Zhang; Ying Mo; Liang-Zhong Sun; Shu-Mei Chen |
Related Documents
:
|
15504946 - Racial and center differences in hemodialysis adequacy in children treated at pediatric... 16611686 - Quality of life in children with chronic kidney disease-patient and caregiver assessments. 3816856 - Ultrasound: a method for kidney size monitoring in children. 9543366 - Glomerular growth in childhood focal segmental glomerulosclerosis. 17133126 - Obesity and asthma: implications for treatment. 3009046 - The inter-regional, epidemiological study of childhood cancer (irescc): case-control st... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-20 |
Journal Detail:
|
Title: World journal of pediatrics : WJP Volume: 5 ISSN: 1708-8569 ISO Abbreviation: - Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-20 Completed Date: 2009-12-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101278599 Medline TA: World J Pediatr Country: China |
Other Details:
|
Languages: eng Pagination: 211-5 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Child Child, Preschool Disease Progression Female Fibronectins / metabolism Glomerulonephritis, IGA / metabolism* Glomerulosclerosis, Focal Segmental Humans Immunoglobulin A / blood Male Smad Proteins / metabolism Smad3 Protein / metabolism Smad7 Protein / metabolism Transforming Growth Factor beta1 / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Fibronectins; 0/Immunoglobulin A; 0/SMAD3 protein, human; 0/SMAD7 protein, human; 0/Smad Proteins; 0/Smad3 Protein; 0/Smad7 Protein; 0/Transforming Growth Factor beta1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression and clinical significance of heparanase in neuroblastoma.
Next Document: Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia.