Document Detail


Expression and significance of TGF-beta1/Smad signaling pathway in children with IgA nephropathy.
MedLine Citation:
PMID:  19693466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: IgA nephropathy (IgAN) exhibits an indolent but slowly progressive course, and about 30% of children with IgAN are found to deteriorate to end-stage renal failure characterized by overaccumulation of extracellular matrix, diffuse glomerular sclerosis, and tubulointerstitial fibrosis. The TGF-beta/Smad signaling pathway plays an important role in glomerulosclerosis and tubulointerstitial fibrosis. The present study aimed to elucidate the significance of expressions of TGF-beta1, phosphorylated Smad3 (p-Smad3), Smad7 and fibronectin (FN) in the renal tissue of children with IgAN. METHODS: Forty-six children with IgAN were divided into 3 groups according to their clinical features: isolated hematuria group (IH group, 8 patients), hematuria and proteinuria group (HP group, 24), and nephritic syndrome group (NS group, 14). Patients were also divided into three groups according to their pathologic grade: grade I+II (22 patients), grade III (12) and grade IV (12) groups. Five normal renal specimens were used as the control group. The expression of TGF-beta1, p-Smad3, Smad7 and FN in renal biopsy specimens was detected by two-step PowerVision. The degrees of renal tubular injury and interstitial fibrosis were scored according to the Katafuchi semi-quantitative criteria. RESULTS: The expression of TGF-beta1, p-Smad3, Smad7 and FN in children with IgAN was significantly higher than that in the control group (in glomeruli: P<0.05, P<0.01, P<0.05 and P<0.01, respectively; in tubulointerstitium: P<0.05, P<0.05, P<0.01 and P<0.05, respectively) and the highest expression levels were found in the NS and grade IV groups (P<0.05, P<0.01). The expression levels of the four proteins were not only positvely correlated with each other, but also with the grade of renal tubular injury and renal interstitial fibrosis (P<0.05). CONCLUSION: The TGF-beta1/Smad signaling pathway plays an important role in the progress of glomerular sclerosis, renal tubular injury and interstitial fibrosis in children with IgAN.
Authors:
Wei Wu; Xiao-Yun Jiang; Qiao-Ling Zhang; Ying Mo; Liang-Zhong Sun; Shu-Mei Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-20
Journal Detail:
Title:  World journal of pediatrics : WJP     Volume:  5     ISSN:  1708-8569     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278599     Medline TA:  World J Pediatr     Country:  China    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Disease Progression
Female
Fibronectins / metabolism
Glomerulonephritis, IGA / metabolism*
Glomerulosclerosis, Focal Segmental
Humans
Immunoglobulin A / blood
Male
Smad Proteins / metabolism
Smad3 Protein / metabolism
Smad7 Protein / metabolism
Transforming Growth Factor beta1 / metabolism*
Chemical
Reg. No./Substance:
0/Fibronectins; 0/Immunoglobulin A; 0/SMAD3 protein, human; 0/SMAD7 protein, human; 0/Smad Proteins; 0/Smad3 Protein; 0/Smad7 Protein; 0/Transforming Growth Factor beta1

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