| Expression of secretory phospholipase A2s in human atherosclerosis development. | |
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MedLine Citation:
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PMID: 17353016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secretory phospholipase A2s (sPLA2s) contribute to the hydrolysis of phospholipid. Among them, sPLA2-IIA, -V, and -X have been regarded as enhancers of lipid accumulation in arterial intima. However, the distribution and production of the other types of sPLA2 in human aortic wall remain unclear. Therefore, in this study, the distribution and production of seven types of sPLA2 including IIA, IID, IIE, IIF, III, V, and X in atherosclerosis development in the human aorta were comprehensively examined by immunohistochemistry and in situ hybridization (ISH). The extent of sPLA2s expression increased with atherosclerosis development, but only sPLA2-IIF was never observed in the normal aorta. Double-immunostaining demonstrated that sPLA2-V expression was limited to smooth muscle cells (SMCs), although the other sPLA2s were expressed in both macrophages and SMCs. ISH using sPLA2 cDNAs revealed that the expression pattern of each mRNA was consistent with the results of immunohistochemistry for each corresponding sPLA2. These results indicate that the seven types of sPLA2 are expressed with various patterns in all stages of atherosclerosis development and may play an atherogenic role through degradation of phospholipid. |
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Authors:
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Masayo Kimura-Matsumoto; Yukio Ishikawa; Kazuo Komiyama; Tadashi Tsuruta; Makoto Murakami; Seiko Masuda; Yoshikiyo Akasaka; Kinji Ito; Shigeki Ishiguro; Hiroshi Morita; Shinji Sato; Toshiharu Ishii |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-13 |
Journal Detail:
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Title: Atherosclerosis Volume: 196 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-02-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 81-91 Citation Subset: IM |
Affiliation:
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Department of Pathology, Toho University, School of Medicine, 5-21-16 Ohmori-nishi, Ohta-ku, Tokyo 143-8540, Japan. m-kimura@med.toho-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Aorta, Abdominal / metabolism Aorta, Thoracic / metabolism Atherosclerosis / enzymology*, metabolism Female Gene Expression Profiling Humans Immunohistochemistry In Situ Hybridization Macrophages / metabolism* Male Middle Aged Myocytes, Smooth Muscle / metabolism* Phospholipases A2, Secretory / metabolism* |
| Chemical | |
Reg. No./Substance:
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EC 3.1.1.4/Phospholipases A2, Secretory |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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