Document Detail


Expression and the role of cathepsin H in human glioma progression and invasion.
MedLine Citation:
PMID:  8640738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proteinases and their inhibitors may play a role in the development and progression of many cancers. Several studies suggested that lysosomal proteinases cathepsin B, L, and D may be involved in the malignant progression of some human neoplastic diseases. In this study, we determined the levels of cathepsin H in human glioma progression and the significance of cathepsin H in glioma cell invasion. Levels of cathepsin H antigen were found to be significantly higher in glioblastomas and anaplastic astrocytoma when compared with normal brain tissue and low-grade gliomas. Western blotting confirmed the presence of authentic cathepsin H with a doublet at 27 and 25 kDa in normal brain tissue and tumor samples. However, the intensity of the band increased significantly in glioblastoma samples. Cathepsin H antibody inhibited the invasion of glioblastoma cell lines through Matrigel invasion assay. These data suggest that the tumor-specific increase in antigen may be a useful independent marker of tumor progression in central nervous system neoplasms.
Authors:
M Sivaparvathi; R Sawaya; Z L Gokaslan; S K Chintala; J S Rao; K S Chintala
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  104     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-15     Completed Date:  1996-07-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Neoplasm / biosynthesis,  metabolism
Blotting, Western
Brain Neoplasms / enzymology*,  pathology*
Cathepsin H
Cathepsins / biosynthesis,  metabolism*
Cysteine Endopeptidases*
Disease Progression
Enzyme-Linked Immunosorbent Assay
Glioma / enzymology*,  pathology*
Humans
Neoplasm Invasiveness
Grant Support
ID/Acronym/Agency:
CA56792/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; EC 3.4.-/Cathepsins; EC 3.4.22.-/Cysteine Endopeptidases; EC 3.4.22.16/CTSH protein, human; EC 3.4.22.16/Cathepsin H
Comments/Corrections
Erratum In:
Cancer Lett 1996 Oct 1;107(1):161
Note: Chintala KS [corrected to Chintala SK]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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