| Expression and regulation of type I BMP receptors during early avian sympathetic ganglion development. | |
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MedLine Citation:
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PMID: 10772803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated the expression and regulation of the mRNAs for the type I BMP receptors, BMPR-IA and BMPR-IB, in quail embryos in vivo and in neural crest cultures in vitro. BMPR-IB mRNA was expressed in the primordial sympathetic ganglia at stage 17, soon after the first expression of Cash-1 mRNA, the avian homolog of the Drosophila transcription factor achaete-scute. BMP-4 mRNA was detected in the dorsal aorta at stage 17, coincident with BMPR-IB mRNA expression in the sympathetic ganglia. BMPR-IA mRNA was first expressed in the sympathetic ganglia at stage 18. Moreover, BMP-4 ligand mRNA was detected in the sympathetic ganglia starting at stage 18. BMPR-IA and BMPR-IB were differentially regulated in cultured neural crest cells. BMPR-IB was expressed in primary outgrowths of neural crest cells but was downregulated after primary outgrowths were harvested and replated in secondary cultures. In secondary cultures of neural crest cells, exogenous BMP-2 and BMP-4 increased the expression of BMPR-IA but decreased the expression of BMPR-IB. The expression of both type I BMP receptors was inhibited by exogenous TGF-beta1. Our results suggest distinct roles for BMPR-IA and BMPR-IB in the development of the sympathoadrenal phenotype from cells of the neural crest. |
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Authors:
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C E McPherson; J E Varley; G D Maxwell |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental biology Volume: 221 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-05-31 Completed Date: 2000-05-31 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 220-32 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Department of Anatomy, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-340512, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF189777; AF189778 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Avian Proteins* Basic Helix-Loop-Helix Transcription Factors Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 4 Bone Morphogenetic Protein Receptors, Type I Bone Morphogenetic Proteins / genetics Cells, Cultured Chick Embryo Cloning, Molecular DNA-Binding Proteins / genetics Ganglia, Sympathetic / embryology* Gene Expression Regulation, Developmental In Situ Hybridization Molecular Sequence Data Neural Crest / embryology* Protein-Serine-Threonine Kinases / chemistry, genetics* Quail / embryology* RNA, Messenger / metabolism Receptors, Growth Factor / chemistry, genetics* Sequence Homology, Amino Acid Transcription Factors / genetics Transforming Growth Factor beta / pharmacology Tyrosine 3-Monooxygenase / genetics |
| Grant Support | |
ID/Acronym/Agency:
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NS 16115/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Avian Proteins; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Bone Morphogenetic Protein 2; 0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/CASH-1 protein, Gallus gallus; 0/DNA-Binding Proteins; 0/RNA, Messenger; 0/Receptors, Growth Factor; 0/Transcription Factors; 0/Transforming Growth Factor beta; EC 1.14.16.2/Tyrosine 3-Monooxygenase; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.30/Bone Morphogenetic Protein Receptors, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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