Document Detail

Expression and regulation of a glutamate receptor subunit by bFGF in oligodendrocyte progenitors.
MedLine Citation:
PMID:  8168868     Owner:  NLM     Status:  MEDLINE    
Oligodendrocyte progenitor cells (O-2A) express both kainate-preferring and AMPA-preferring glutamate receptors (Gallo et al., Soc. Neurosci. Abstr., 18:653, 1992b; Gallo et al., 1994). The expression and regulation of the GluR-4c, AMPA-preferring subunit by growth factors was studied by Northern blot analysis of total RNA from purified rat cortical O-2A progenitors. Differently from cortical neurons, O-2A progenitors only expressed two high molecular weight GluR-4c transcripts (6.2 and 4.2 kb), as observed also in cultured astrocytes. Basic fibroblast growth factor (bFGF) increased GluR-4c transcript levels in O-2A progenitors and its effects were not mimicked by platelet derived growth factor (PDGF) or fetal calf serum. Therefore, bFGF may regulate O-2A progenitor responsiveness to glutamate during development through the expression of glutamate receptor subunits.
V Gallo; P Wright; R D McKinnon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Glia     Volume:  10     ISSN:  0894-1491     ISO Abbreviation:  Glia     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-01     Completed Date:  1994-06-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-53     Citation Subset:  IM    
Unit on Neurobiology, NICHD, National Institutes of Health, Bethesda, Maryland 20892.
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MeSH Terms
Blotting, Northern
Cerebral Cortex / cytology
Fibroblast Growth Factor 2 / pharmacology*
Molecular Weight
Oligodendroglia / metabolism*
Platelet-Derived Growth Factor / pharmacology
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Receptors, Glutamate / chemistry,  genetics,  metabolism*
Stem Cells / metabolism*
Reg. No./Substance:
0/Platelet-Derived Growth Factor; 0/RNA, Messenger; 0/Receptors, Glutamate; 103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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