Document Detail

Expression and regulation of Xenopus CRMP-4 in the developing nervous system.
MedLine Citation:
PMID:  17554687     Owner:  NLM     Status:  MEDLINE    
The collaspin response mediator proteins (CRMPs) are a family of cytosolic phosphoproteins which play a critical role in the establishment of neuronal polarity and growth cone guidance. Here, we describe the temporal and spatial expression of CRMP-4 during early Xenopus embryogenesis. CRMP-4 transcripts were first detected by whole mount in situ hybridization at the end of gastrulation in the prospective neuroectoderm. During open neural plate stages, CRMP-4 was expressed broadly throughout the anterior neural plate and in the three bilateral stripes of the posterior neural plate where primary neurons arise. The expression in the territories of primary neurogenesis prefigures that of the post-mitotic neuronal marker N-tubulin. At tadpole stages, expression was maintained throughout the central nervous system and in the retina of the eye. Consistent with the observed expression, CRMP-4 transcripts are positively regulated by X-ngnr-1 and negatively by Notch signaling. The observed expression and regulation of CRMP-4 differ from that of the CRMP-2, which is induced by the events of neural induction.
Jacob Souopgui; Tiemo J Klisch; Tomas Pieler; Kristine A Henningfeld
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of developmental biology     Volume:  51     ISSN:  0214-6282     ISO Abbreviation:  Int. J. Dev. Biol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-07     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917470     Medline TA:  Int J Dev Biol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  339-43     Citation Subset:  IM    
DFG-Center of Molecular Physiology of the Brain, Department of Developmental Biochemistry, University of Goettingen, Goettingen, Germany.
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MeSH Terms
Amino Acid Sequence
Central Nervous System / embryology,  metabolism
Embryo, Nonmammalian
Gene Expression Regulation, Developmental*
In Situ Hybridization
Molecular Sequence Data
Nerve Tissue Proteins / genetics*,  metabolism*
Nervous System / cytology,  embryology*,  metabolism
Neurons / cytology,  metabolism
Open Reading Frames
Phosphoproteins / genetics*,  metabolism*
Retina / embryology,  metabolism
Sequence Homology, Amino Acid
Xenopus / embryology*
Xenopus Proteins / genetics*,  metabolism*
Reg. No./Substance:
0/CRMP-4 protein, Xenopus; 0/Nerve Tissue Proteins; 0/Phosphoproteins; 0/Xenopus Proteins

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