| Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. | |
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MedLine Citation:
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PMID: 12460879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes and hypothesized that ST2 participates in the acute myocardial response to stress and injury. METHODS AND RESULTS: ST2 mRNA was induced in cardiac myocytes by mechanical strain (4.7+/-0.9-fold) and interleukin-1beta (2.0+/-0.2-fold). Promoter analysis revealed that the proximal and not the distal promoter of ST2 is responsible for transcriptional activation in cardiac myocytes by strain and interleukin-1beta. In mice subjected to coronary artery ligation, serum ST2 was transiently increased compared with unoperated controls (20.8+/-4.4 versus 0.8+/-0.8 ng/mL, P<0.05). Soluble ST2 levels were increased in the serum of human patients (N=69) 1 day after myocardial infarction and correlated positively with creatine kinase (r=0.41, P<0.001) and negatively with ejection fraction (P=0.02). CONCLUSIONS: These data identify ST2 release in response to myocardial infarction and suggest a role for this innate immune receptor in myocardial injury. |
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Authors:
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Ellen O Weinberg; Masahisa Shimpo; Gilles W De Keulenaer; Catherine MacGillivray; Shin-ichi Tominaga; Scott D Solomon; Jean-Lucien Rouleau; Richard T Lee |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 106 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-03 Completed Date: 2002-12-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 2961-6 Citation Subset: AIM; IM; S |
Affiliation:
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Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Mass 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology Animals Animals, Newborn Biological Markers / blood Cells, Cultured Disease Models, Animal Gene Expression Regulation / drug effects, physiology Humans Imidazoles / pharmacology Interleukin-1 / pharmacology Interleukin-4 / pharmacology Lipopolysaccharides / pharmacology Membrane Proteins / blood, genetics, metabolism* Mice Mice, Inbred C57BL Myocardial Infarction / blood, metabolism* Myocardium / cytology, metabolism* Nuclease Protection Assays Phorbol Esters / pharmacology Promoter Regions, Genetic / drug effects, physiology Pyridines / pharmacology RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 Receptors, Angiotensin / antagonists & inhibitors Receptors, Cell Surface Receptors, Interleukin Receptors, Interleukin-1 / blood, genetics, metabolism* Stress, Mechanical Stroke Volume |
| Grant Support | |
ID/Acronym/Agency:
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HL052320/HL/NHLBI NIH HHS; HL63927/HL/NHLBI NIH HHS; HL69484/HL/NHLBI NIH HHS; R01 HL069484-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CP 191166; 0/IL1RL1 protein, human; 0/Il1rl1 protein, mouse; 0/Imidazoles; 0/Interleukin-1; 0/Lipopolysaccharides; 0/Membrane Proteins; 0/Phorbol Esters; 0/Pyridines; 0/RNA, Messenger; 0/Receptor, Angiotensin, Type 1; 0/Receptors, Angiotensin; 0/Receptors, Cell Surface; 0/Receptors, Interleukin; 0/Receptors, Interleukin-1; 11128-99-7/Angiotensin II; 207137-56-2/Interleukin-4 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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