| Expression of receptors for advanced glycosylation end products on renal cell carcinoma cells in vitro. | |
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MedLine Citation:
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PMID: 8240377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Proteins that have been modified by long-term expose to glucose accumulate advanced glycosylation end products (AGEs) as a function of protein age. In these studies, we have examined the interaction of AGE-protein with renal cell carcinoma cells (RCC) in vitro, using AGE-modified bovine serum albumin (AGE-BSA) as a probe. AGE-BSA showed tendency to induce in vitro cell growth of RCC cells and promoted the production of interleukin-6 (IL-6), an in vitro autocrine growth factor. Reverse transcriptase-polymerase chain reaction analysis revealed that RCC cells used here express mRNA for a receptor for AGEs (RAGE). These results suggested that AGEs taken up through RAGE on RCC cells might play a role in promoting the growth of RCC cells. |
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Authors:
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S Miki; S Kasayama; Y Miki; Y Nakamura; M Yamamoto; B Sato; T Kishimoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 196 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-12-09 Completed Date: 1993-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 984-9 Citation Subset: IM |
Affiliation:
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Nissei Hospital, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Clear Cell
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metabolism Base Sequence Carcinoma, Renal Cell / metabolism* Cell Division Cells, Cultured DNA Primers Endothelium, Vascular / metabolism Gene Expression Glycosylation End Products, Advanced / metabolism*, pharmacology* Humans Interleukin-6 / biosynthesis Molecular Sequence Data Polymerase Chain Reaction / methods RNA, Messenger / analysis, biosynthesis Receptors, Immunologic / biosynthesis* Tumor Cells, Cultured Umbilical Veins Urinary Bladder Neoplasms / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Glycosylation End Products, Advanced; 0/Interleukin-6; 0/RNA, Messenger; 0/Receptors, Immunologic; 0/advanced glycosylation end-product receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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