Document Detail


Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.
MedLine Citation:
PMID:  9410895     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protein kinase C (PKC) activation in the heart has been linked to a hypertrophic phenotype and to processes that influence contractile function. To establish whether PKC activation is sufficient to induce an abnormal phenotype, PKCbeta was conditionally expressed in cardiomyocytes of transgenic mice. Transgene expression in adults caused mild and progressive ventricular hypertrophy associated with impaired diastolic relaxation, whereas expression in newborns caused sudden death associated with marked abnormalities in the regulation of intracellular calcium. Thus, the PKC signaling pathway in cardiocytes has different effects depending on the timing of expression and, in the adult, is sufficient to induce pathologic hypertrophy.
Authors:
J C Bowman; S F Steinberg; T Jiang; D L Geenen; G I Fishman; P M Buttrick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  100     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-23     Completed Date:  1997-12-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2189-95     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Albert Einstein College of Medicine, New York, NY 10461, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Body Weight
Calcium / physiology
Cardiomegaly / enzymology*
Death, Sudden
Female
Isoenzymes / metabolism*
Isoproterenol / pharmacology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myocardium / enzymology*
Protein Kinase C / metabolism*
Sarcomeres / physiology
Grant Support
ID/Acronym/Agency:
HL-15498/HL/NHLBI NIH HHS; HL-45937/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 7440-70-2/Calcium; 7683-59-2/Isoproterenol; EC 2.7.1.-/protein kinase C beta; EC 2.7.11.13/Protein Kinase C
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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