| Expression of protease activated receptor-2 in human colorectal cancer and its association with tumor progression. | |
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MedLine Citation:
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PMID: 20628286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Protease activated receptor-2 has been reported to promote the proliferation of colorectal cancer cells. The aim of this study was to investigate the relationship of protease activated receptor-2 expression to clinicopathologic factors to clarify its role in tumor progression and patient survival in human colorectal cancer. METHODS: Immunohistochemical staining with anti-protease activated receptor-2 antibody was carried out and evaluated on samples from 295 patients with colorectal cancer obtained during surgical treatment at Kangnam St. Mary's Hospital, Seoul, Republic of Korea. Medical records were reviewed and relationships between immunostaining and clinicopathologic findings were evaluated. RESULTS: Positive staining for protease activated receptor-2 was observed in samples from 100 patients (33.9%). Expression of protease activated receptor-2 was significantly associated with depth of tumor invasion (P = .013), liver metastasis (P = .008), TNM stage (P = .009), and tumor location (P = .011). However, protease activated receptor-2 expression did not significantly correlate with overall survival of patients and was not a significant negative prognostic factor for survival in univariate or multivariate analyses. CONCLUSIONS: The expression of protease activated receptor-2 is related to tumor invasion and metastasis in human colorectal cancer. However, further studies are needed to clarify the role of protease activated receptor-2 in the prognosis of patients with colorectal cancer. |
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Authors:
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Jae Hyuck Chang; Jae Myung Park; Sang Woo Kim; Chan Kwon Jung; Won Kyung Kang; Seong Taek Oh |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 53 ISSN: 1530-0358 ISO Abbreviation: Dis. Colon Rectum Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: United States |
Other Details:
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Languages: eng Pagination: 1202-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation Colonoscopy Colorectal Neoplasms / enzymology*, mortality, pathology Disease Progression Female Follow-Up Studies Humans Immunohistochemistry Korea / epidemiology Male Middle Aged Neoplasm Staging Receptor, PAR-2 / biosynthesis* Retrospective Studies Survival Rate / trends Time Factors Tumor Markers, Biological / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Receptor, PAR-2; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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