Document Detail

Expression of protease-activated receptor 1 in oral squamous cell carcinoma.
MedLine Citation:
PMID:  11431106     Owner:  NLM     Status:  MEDLINE    
Protease-activated receptor 1 (PAR-1) is a G-coupled membrane protein. In this study, we analyzed the expression of PAR-1 in oral squamous cell carcinomas (SCCs). PAR-1 was expressed in oral SCCs, but the level of PAR-1 protein was lower in non-metastatic cells than in metastatic cells. Thrombin stimulated the growth of metastatic cells, and both thrombin and thrombin receptor activation peptide (TRP) enhanced the adhesion of these cells to fibronectin, but had no effect on non-metastatic cells. Thrombin and TRP also induced matrix metalloproteinase (MMP)-2 and MMP-9 activities in metastatic cells. These results suggest that PAR-1 may contribute to the growth and invasive potential of oral SCC.
Y Liu; M Z Gilcrease; Y Henderson; X H Yuan; G L Clayman; Z Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  169     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-06-29     Completed Date:  2001-08-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  173-80     Citation Subset:  IM    
Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Box 441, 77030, Houston, TX, USA.
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MeSH Terms
Blotting, Western
Caenorhabditis elegans Proteins*
Carcinoma, Squamous Cell / metabolism*
Cell Adhesion
Cell Division
Cell Line
Fibronectins / metabolism
Matrix Metalloproteinase 2 / biosynthesis
Matrix Metalloproteinase 9 / biosynthesis
Matrix Metalloproteinases / metabolism
Mouth Neoplasms / metabolism*
Protein-Serine-Threonine Kinases / metabolism
Proteins / pharmacology
RNA, Messenger / metabolism
Receptor, PAR-1
Receptors, Thrombin / biosynthesis*
Reverse Transcriptase Polymerase Chain Reaction
Thrombin / metabolism,  pharmacology
Tumor Cells, Cultured
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Fibronectins; 0/Proteins; 0/RNA, Messenger; 0/Receptor, PAR-1; 0/Receptors, Thrombin; EC Kinases; EC; EC 3.4.24.-/Matrix Metalloproteinases; EC Metalloproteinase 2; EC Metalloproteinase 9

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