Document Detail


Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy.
MedLine Citation:
PMID:  17827166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serine proteases and their cognate serpin-class inhibitors are involved in the controlled proteolytic events during follicular development, ovulation, formation, and maintenance of the corpus luteum (CL). In this study, we investigated the expression patterns of prostasin serine protease and protease nexin-1 (PN-1), a serine protease inhibitor also called serpin-E2, in rhesus monkey ovaries during the menstrual cycle and early pregnancy, by using in situ hybridization and immunohistochemistry. Expression of prostasin was localized in oocyte, granulosa cells, and/or theca cells of early antral follicles and antral follicles, with high levels observed in preovulatory follicles. Prostasin was also localized at high levels of abundance in the CL during the menstrual cycle and early pregnancy. During the menstrual cycle, PN-1 was coordinately localized with prostasin in oocytes, granulosa cells, and theca cells of antral follicles and preovulatory follicles and in the CL. In addition, the PN-1 expression level in macaque CL during early pregnancy increased as pregnancy proceeded. We propose that prostasin may be involved in follicular development, ovulation, and CL formation, whereas PN-1 may be present to regulate the proteolysis in these processes.
Authors:
Heng Zhang; Hai-Yan Lin; Qing Yang; Hong-Xing Wang; Karl X Chai; Li-Mei Chen; Cheng Zhu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-09-06
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  55     ISSN:  0022-1554     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1237-44     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein Precursor / biosynthesis*,  genetics
Animals
Female
Immunohistochemistry
Macaca mulatta
Menstrual Cycle / metabolism*
Ovary / cytology,  metabolism*
Pregnancy
Pregnancy, Animal / metabolism*
RNA, Messenger / biosynthesis
Receptors, Cell Surface / biosynthesis*,  genetics
Serine Endopeptidases / biosynthesis*,  genetics
Grant Support
ID/Acronym/Agency:
HD 40241/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein Precursor; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/protease nexins; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/prostasin

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